Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Glycogen phosphorylase, muscle form | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Glycogen phosphorylase, muscle form | 843 aa | 840 aa | 70.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0056 | 0.1642 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0988 | 0.146 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.6767 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0988 | 0.146 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0988 | 0.0988 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.013 | 0.6767 | 0.6767 |
Schistosoma mansoni | glycogen phosphorylase | 0.0056 | 0.1642 | 0.1642 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0988 | 0.0988 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0988 | 0.0988 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.6767 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.4888 | 0.7222 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.6767 | 0.6767 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.6767 | 0.6767 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2625 | 0.3879 |
Chlamydia trachomatis | glycogen phosphorylase | 0.013 | 0.6767 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.013 | 0.6767 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.6767 | 0.6767 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0988 | 0.0988 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.6767 | 0.6767 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.2625 | 0.3879 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0988 | 0.0988 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.6767 | 0.6767 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.6767 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.013 | 0.6767 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.013 | 0.6767 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.013 | 0.6767 | 0.6767 |
Echinococcus multilocularis | geminin | 0.0177 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.013 | 0.6767 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0988 | 0.0988 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.4888 | 0.7222 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.6767 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.4888 | 0.7222 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0056 | 0.1642 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.6767 | 0.6767 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.4888 | 0.7222 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.2625 | 0.2625 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0988 | 0.0988 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
FC (binding) | = 1.09 | Activation of human glucokinase expressed in Escherichia coli BL21(DE3) at 10 uM by G6PDH-coupled spectrometry relative to untreated control | ChEMBL. | 19758809 |
IC50 (binding) | = 9.8 uM | Inhibition of rabbit muscle glycogen phosphorylase a assessed as glucose-1-phosphate release | ChEMBL. | 19758809 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.