Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | protein tyrosine phosphatase 1 | 0.0145 | 0 | 0.5 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0145 | 0 | 0.5 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0145 | 0 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.1281 | 0.1979 | 1 |
Leishmania major | tyrosine specific protein phosphatase, putative | 0.0145 | 0 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.1281 | 0.1979 | 0.1979 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.5884 | 1 | 1 |
Onchocerca volvulus | 0.5884 | 1 | 1 | |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0145 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.1281 | 0.1979 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.1281 | 0.1979 | 0.1979 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.1281 | 0.1979 | 1 |
Onchocerca volvulus | 0.5884 | 1 | 1 | |
Leishmania major | protein-tyrosine phosphatase 1-like protein | 0.0145 | 0 | 0.5 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0145 | 0 | 0.5 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0145 | 0 | 0.5 |
Trichomonas vaginalis | pten, drome, putative | 0.0145 | 0 | 0.5 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0145 | 0 | 0.5 |
Giardia lamblia | Protein tyrosine phosphatase | 0.0145 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
C (functional) | = 0.016 uM | Effective concentration for delaying effective refractory period (ERP) 10 ms in guinea pig | ChEMBL. | 12086482 |
Delta ERP (functional) | = 17.5 % | Percent change for delaying effective refractory period (ERP) in guinea pig at 10e-5 M concentration | ChEMBL. | 12086482 |
Delta FC (functional) | = 24.8 % | Percent change of force of constriction measured in guinea pig at 10e-5 M concentration | ChEMBL. | 12086482 |
Delta HR (functional) | = -32 % | Percent change in heart rate measured in guinea pig at 10e-5 M concentration | ChEMBL. | 12086482 |
EA (functional) | = 7.8 | Negative log of concentration (-logC)for delaying functional refractory period 10 ms in animal atrium | ChEMBL. | 11012018 |
Effective concentration (functional) | = 0.016 uM | Tested for its effective concentration for delaying functional refractory period 10 ms in animal atrium | ChEMBL. | 11012018 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.