Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0182916 | 0.970282 | 0.961281 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0186792 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0186792 | 1 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0186792 | 1 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0186792 | 1 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.0186792 | 1 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0186792 | 1 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0186792 | 1 | 0.5 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0186792 | 1 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0186792 | 1 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0186792 | 1 | 0.5 |
Onchocerca volvulus | Putative GMP reductase | 0.00828066 | 0.202749 | 1 |
Brugia malayi | GMP reductase | 0.00828066 | 0.202749 | 0.202749 |
Trypanosoma brucei | GMP reductase | 0.0186792 | 1 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0186792 | 1 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.010011 | 0.335409 | 0.13412 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0186792 | 1 | 0.5 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0186792 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0186792 | 1 | 0.5 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0186792 | 1 | 0.5 |
Loa Loa (eye worm) | GMP reductase | 0.00828066 | 0.202749 | 0.202749 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.00828066 | 0.202749 | 0.202749 |
Toxoplasma gondii | IMP dehydrogenas | 0.0186792 | 1 | 0.5 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0182916 | 0.970282 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.00828066 | 0.202749 | 0.202749 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0182916 | 0.970282 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0186792 | 1 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0186792 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 1.5909 uM | ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
EC50 (functional) | 6.627 uM | ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.