Activity (functional)
|
|
Inhibition of phenylephrine-stimulated Wistar rat aorta contraction at 10 uM
|
ChEMBL.
|
16513345
|
Activity (functional)
|
|
Inhibition of phenylephrine-stimulated Wistar rat aorta contraction at 100 uM
|
ChEMBL.
|
16513345
|
Activity (functional)
|
0
|
Inhibition of phenylephrine-stimulated Wistar rat aorta contraction at 10 uM
|
ChEMBL.
|
16513345
|
Activity (functional)
|
0
|
Inhibition of phenylephrine-stimulated Wistar rat aorta contraction at 100 uM
|
ChEMBL.
|
16513345
|
EC50 (functional)
|
|
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
|
ChEMBL.
|
16513345
|
EC50 (functional)
|
|
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
|
ChEMBL.
|
16513345
|
EC50 (functional)
|
0
|
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
|
ChEMBL.
|
16513345
|
EC50 (functional)
|
0
|
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
|
ChEMBL.
|
16513345
|
IC50 (functional)
|
0 ug ml-1
|
Inhibitory concentration against ferriprotoporphyrin in biomineralisation assay (FBIT); Not active
|
ChEMBL.
|
12873511
|
IC50 (functional)
|
= 1 ug ml-1
|
In vitro inhibitory concentration against Plasmodium falciparum (F32)
|
ChEMBL.
|
12873511
|
IC50 (functional)
|
= 1 ug ml-1
|
In vitro inhibitory concentration against Plasmodium falciparum (F32)
|
ChEMBL.
|
12873511
|
IC50 (functional)
|
= 45 ug ml-1
|
In vitro inhibitory activity against Leishmania braziliensis (M2903)
|
ChEMBL.
|
11514152
|
IC50 (functional)
|
= 45 ug ml-1
|
In vitro inhibitory activity against Leishmania amazonensis (PH8)
|
ChEMBL.
|
11514152
|
IC50 (functional)
|
= 45 ug ml-1
|
In vitro inhibitory activity against Leishmania donovani (PP75)
|
ChEMBL.
|
11514152
|
IC50 (functional)
|
= 45 ug ml-1
|
Inhibitory concentration of the compound against Epimastigotes (Tulahuen strain) of Trypanosoma cruzi
|
ChEMBL.
|
11591517
|
IC50 (functional)
|
= 45 ug ml-1
|
In vitro inhibitory activity against Leishmania braziliensis (M2903)
|
ChEMBL.
|
11514152
|
IC50 (functional)
|
= 45 ug ml-1
|
In vitro inhibitory activity against Leishmania donovani (PP75)
|
ChEMBL.
|
11514152
|
IC50 (functional)
|
= 45 ug ml-1
|
Inhibitory concentration of the compound against Epimastigotes (Tulahuen strain) of Trypanosoma cruzi
|
ChEMBL.
|
11591517
|
IC50 (functional)
|
> 100 ug ml-1
|
Inhibitory concentration against trypomastigotes (Y strain) of Trypanosoma cruzi; Inactive
|
ChEMBL.
|
11591517
|
IC50 (functional)
|
> 100 ug ml-1
|
Inhibitory concentration against trypomastigotes (Y strain) of Trypanosoma cruzi; Inactive
|
ChEMBL.
|
11591517
|
IC50 (functional)
|
0 uM
|
In vitro inhibitory concentration against ferriprotoporphyrin in biomineralisation assay (FBIT); Not active
|
ChEMBL.
|
12873511
|
IC50 (functional)
|
= 3.6 uM
|
In vitro inhibitory concentration against Plasmodium falciparum (F32)
|
ChEMBL.
|
12873511
|
IC50 (functional)
|
= 3.6 uM
|
In vitro inhibitory concentration against Plasmodium falciparum (F32)
|
ChEMBL.
|
12873511
|
IC50 (functional)
|
= 161.8 uM
|
Inhibitory concentration of the compound against Epimastigotes (Tulahuen strain) of Trypanosoma cruzi
|
ChEMBL.
|
11591517
|
IC50 (functional)
|
= 161.8 uM
|
Inhibitory concentration of the compound against Epimastigotes (Tulahuen strain) of Trypanosoma cruzi
|
ChEMBL.
|
11591517
|
Index (functional)
|
= 1.1 %
|
Antiplasmodial potency of the compound measured relative to chloroquine (IC50 chloroquine / IC50 compound)
|
ChEMBL.
|
12873511
|
Index (functional)
|
= 1.1 %
|
Antiplasmodial potency of the compound measured relative to chloroquine (IC50 chloroquine / IC50 compound)
|
ChEMBL.
|
12873511
|
Inhibition (functional)
|
|
Inhibition of noradrenaline-stimulated Wistar rat vas deferens contraction at 10 uM
|
ChEMBL.
|
16513345
|
Inhibition (functional)
|
|
Inhibition of noradrenaline-stimulated Wistar rat vas deferens contraction at 1 uM
|
ChEMBL.
|
16513345
|
Inhibition (functional)
|
0
|
Inhibition of noradrenaline-stimulated Wistar rat vas deferens contraction at 1 uM
|
ChEMBL.
|
16513345
|
Inhibition (functional)
|
0
|
Inhibition of noradrenaline-stimulated Wistar rat vas deferens contraction at 10 uM
|
ChEMBL.
|
16513345
|
pD'2 (binding)
|
|
Affinity to Adrenergic alpha1B receptor in Wistar rat spleen
|
ChEMBL.
|
16513345
|
pD'2 (binding)
|
|
Affinity to Adrenergic alpha1A receptor in Wistar rat vas deferens
|
ChEMBL.
|
16513345
|
pD'2 (binding)
|
|
Affinity to Adrenergic alpha1D receptor in Wistar rat aorta
|
ChEMBL.
|
16513345
|
pD'2 (binding)
|
0
|
Affinity to Adrenergic alpha1A receptor in Wistar rat vas deferens
|
ChEMBL.
|
16513345
|
pD'2 (binding)
|
0
|
Affinity to Adrenergic alpha1B receptor in Wistar rat spleen
|
ChEMBL.
|
16513345
|
pD'2 (binding)
|
0
|
Affinity to Adrenergic alpha1D receptor in Wistar rat aorta
|
ChEMBL.
|
16513345
|
Ratio (functional)
|
= 5.4
|
Ratio of inhibitory concentration of the compound to that of reference drug was determined
|
ChEMBL.
|
11591517
|