Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 8 % | Cytotoxicity against human Jurkat T cells assessed as cell death at 10 uM after 24 hrs by flow cytometry | ChEMBL. | 20034801 |
Activity (functional) | = 8 % | Induction of apoptosis in human Jurkat T cells at 10 uM after 24 hrs by flow cytometry | ChEMBL. | 20034801 |
Activity (functional) | = 30 % | Induction of apoptosis in human Jurkat T cells at 100 uM after 24 hrs by flow cytometry | ChEMBL. | 20034801 |
Activity (functional) | = 33 % | Cytotoxicity against human Jurkat T cells assessed as cell death at 100 uM after 24 hrs by flow cytometry | ChEMBL. | 20034801 |
Activity (functional) | = 90 % | Cytotoxicity against human Jurkat T cells assessed as viable cells at 10 uM after 24 hrs by flow cytometry | ChEMBL. | 20034801 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.