Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | abhydrolase domain containing 6 | Starlite/ChEMBL | References |
Mus musculus | monoglyceride lipase | Starlite/ChEMBL | References |
Mus musculus | fatty acid amide hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | monoglyceride lipase | 258 aa | 241 aa | 22.0 % |
Trypanosoma cruzi | amidase, putative | fatty acid amide hydrolase | 579 aa | 467 aa | 26.6 % |
Plasmodium falciparum | epoxide hydrolase 2 | abhydrolase domain containing 6 | 336 aa | 295 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Schistosoma mansoni | amidase | 0.0123 | 0.0937 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.0937 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Plasmodium vivax | PST-A protein | 0.0084 | 0 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.0937 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.0499 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0937 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.0937 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.0937 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.0937 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0084 | 0 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.009 | 0.0148 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Brugia malayi | amidase | 0.0123 | 0.0937 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 90 nM | Inhibition of MAGL in mouse brain membrane | ChEMBL. | 20099888 |
IC50 (binding) | = 310 nM | Inhibition of ABHD6 in mouse brain membrane | ChEMBL. | 20099888 |
IC50 (binding) | = 930 nM | Inhibition of FAAH in mouse brain membrane | ChEMBL. | 20099888 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.