Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Tolloid protein 1 | 0.1316 | 0.5603 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1812 | 1 | 1 |
Echinococcus multilocularis | laminin | 0.1316 | 0.5603 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1812 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1812 | 1 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.1316 | 0.5603 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1812 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.1316 | 0.5603 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.1316 | 0.5603 | 1 |
Onchocerca volvulus | 0.1812 | 1 | 1 | |
Onchocerca volvulus | 0.143 | 0.6618 | 0.2308 | |
Echinococcus multilocularis | Tolloid protein 1 | 0.1316 | 0.5603 | 0.5 |
Echinococcus granulosus | laminin | 0.1316 | 0.5603 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | Percent inhibition of bronchospasm in vivo at a dose of 12.5 mg/kg in guinea pig | ChEMBL. | 2903244 |
Inhibition (functional) | = 52 % | Percent inhibition of SRS-A release in vitro at a dose of 10 microM in guinea pig | ChEMBL. | 2903244 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.