Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase-activating protein | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | thioredoxin reductase | 0.0104 | 0.254 | 0.6836 |
Brugia malayi | Thioredoxin reductase | 0.0104 | 0.254 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0263 | 0.7773 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0104 | 0.254 | 1 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0135 | 0.3571 | 0.3363 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0263 | 0.7773 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0104 | 0.254 | 1 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0135 | 0.3571 | 0.3363 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.1305 | 0.1024 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0237 | 0.6906 | 0.8837 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1305 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0104 | 0.254 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0036 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0237 | 0.6906 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0036 | 0.0313 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0036 | 0.0313 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1305 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0036 | 0.0313 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0104 | 0.254 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0104 | 0.254 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0036 | 0.0313 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0104 | 0.254 | 0.6836 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0104 | 0.254 | 0.2985 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0036 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.1305 | 0.1329 |
Plasmodium vivax | glutathione reductase, putative | 0.0104 | 0.254 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.1305 | 0.3044 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0237 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0263 | 0.7773 | 1 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0135 | 0.3571 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.1305 | 0.4453 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0263 | 0.7773 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0237 | 0.6906 | 0.8837 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.1305 | 0.3044 |
Leishmania major | trypanothione reductase | 0.0104 | 0.254 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0104 | 0.254 | 0.6836 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0135 | 0.3571 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0104 | 0.254 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1305 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0237 | 0.6906 | 0.8837 |
Toxoplasma gondii | MAPEG family protein | 0.0135 | 0.3571 | 1 |
Brugia malayi | glutathione reductase | 0.0104 | 0.254 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0036 | 0.0313 | 0.1234 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0036 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0237 | 0.6906 | 0.8837 |
Trypanosoma brucei | trypanothione reductase | 0.0104 | 0.254 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.1305 | 0.3044 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.1305 | 0.1024 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 581 nM | Binding affinity to FLAP in human PMN derived membrane | ChEMBL. | 19914828 |
IC50 (functional) | = 23111 nM | Inhibition of LTB4 production in calcium ionophore treated A23187 human whole blood after 15 mins | ChEMBL. | 19914828 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.