Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0105 | 1 | 1 |
Brugia malayi | Transient-receptor-potential like protein | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.007 | 0.4609 | 0.4609 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.007 | 0.4609 | 0.4609 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0105 | 1 | 1 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0102 | 0.9469 | 0.9469 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.007 | 0.4609 | 0.4609 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0105 | 1 | 1 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0102 | 0.9469 | 0.9469 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.007 | 0.4609 | 0.4609 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4079 | 0.4079 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 35 % | Growth inhibition of human KB cells at 10 uM after 72 hrs by MTS assay | ChEMBL. | 19822434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.