Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0042 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0319 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.2059 | 0.2059 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0066 | 0.0848 | 0.0848 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0218 | 0.6319 | 0.6929 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0066 | 0.0848 | 0.0848 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.01 | 0.2059 | 0.2059 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0096 | 0.194 | 0.194 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0127 | 0.3042 | 0.3881 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0319 | 0.0319 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0236 | 0.6958 | 0.8878 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0067 | 0.088 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0728 | 0.0728 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0066 | 0.0848 | 0.0848 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0218 | 0.6319 | 0.6319 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.01 | 0.2059 | 0.2059 |
Loa Loa (eye worm) | glutamate receptor | 0.0261 | 0.7838 | 0.7838 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.088 | 0.088 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.01 | 0.2059 | 0.2258 |
Schistosoma mansoni | transient receptor potential channel | 0.0066 | 0.0848 | 0.0929 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0319 | 0.0407 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0067 | 0.088 | 0.088 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0218 | 0.6319 | 0.6319 |
Schistosoma mansoni | transient receptor potential channel | 0.01 | 0.2059 | 0.2258 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0103 | 0.2162 | 0.2162 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0127 | 0.3042 | 0.3335 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0096 | 0.194 | 0.194 |
Schistosoma mansoni | transient receptor potential channel | 0.0066 | 0.0848 | 0.0929 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0066 | 0.0848 | 0.0848 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0297 | 0.912 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0067 | 0.088 | 0.1122 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0319 | 0.0319 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0261 | 0.7838 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 275 uM | Inhibition of inosine monophosphate dehydrogenase in Escherichia coli | ChEMBL. | 6120232 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.