Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | monoglyceride lipase | Starlite/ChEMBL | References |
Mus musculus | fatty acid amide hydrolase | Starlite/ChEMBL | References |
Mus musculus | abhydrolase domain containing 6 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | monoglyceride lipase | 258 aa | 241 aa | 22.0 % |
Trypanosoma cruzi | amidase, putative | fatty acid amide hydrolase | 579 aa | 467 aa | 26.6 % |
Plasmodium falciparum | epoxide hydrolase 2 | abhydrolase domain containing 6 | 336 aa | 295 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0159 | 0.1805 | 0.6275 |
Plasmodium vivax | PST-A protein | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.0159 | 0.1805 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.018 | 0.232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1805 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0159 | 0.1805 | 0.6275 |
Echinococcus multilocularis | geminin | 0.018 | 0.232 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0084 | 0 | 0.5 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.0499 | 1 | 1 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.009 | 0.0148 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.232 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0159 | 0.1805 | 0.6275 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0084 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.232 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1805 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 nM | Inhibition of MAGL in mouse brain membrane | ChEMBL. | 20099888 |
IC50 (binding) | = 280 nM | Inhibition of FAAH in mouse brain membrane | ChEMBL. | 20099888 |
IC50 (binding) | = 1000 nM | Inhibition of ABHD6 in mouse brain membrane | ChEMBL. | 20099888 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.