Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glycogen phosphorylase | 0.0982 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0982 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0982 | 0.5 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0982 | 0.5 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0982 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0982 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0982 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0982 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0982 | 0.5 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0982 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0982 | 0.5 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0982 | 0.5 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0982 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0982 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0982 | 0.5 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0982 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 13.81 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infected in rat L6 cells after 72 hrs by alamar blue assay | ChEMBL. | 22390399 |
EC50 (functional) | = 21.7 uM | Antitrypanosomal activity against diminazene-, pentamidine-, and melaminophenyl arsenical-resistant HAPT1-deficient Trypanosoma brucei brucei B48 after 3 days by alamar blue assay | ChEMBL. | 22390399 |
EC50 (functional) | = 33.8 uM | Antitrypanosomal activity against diminazene aceturate-resistant TbAT1 gene-deficient Trypanosoma brucei brucei AT1-KO after 3 days by alamar blue assay | ChEMBL. | 22390399 |
EC50 (functional) | = 36.9 uM | Antitrypanosomal activity against wild type Trypanosoma brucei brucei Lister 427 after 3 days by alamar blue assay | ChEMBL. | 22390399 |
LC50 (functional) | = 18.12 uM | Antileishmanial activity against Leishmania donovani MHOM/SC/00/1S-2D promastigotes after 48 hrs by MTT assay | ChEMBL. | 20128602 |
Ratio EC50 (functional) | = 0.6 | Resistance factor, ratio of EC50 for diminazene-, pentamidine-, and melaminophenyl arsenical-resistant HAPT1-deficient Trypanosoma brucei brucei B48 to EC50 for wild type Trypanosoma brucei brucei Lister 427 | ChEMBL. | 22390399 |
Ratio EC50 (functional) | = 0.9 | Resistance factor, ratio of EC50 for diminazene aceturate-resistant TbAT1 gene-deficient Trypanosoma brucei brucei AT1-KO to EC50 for wild type Trypanosoma brucei brucei Lister 427 | ChEMBL. | 22390399 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 22390399 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.