Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arginine vasopressin receptor 1A | Starlite/ChEMBL | References |
Homo sapiens | oxytocin receptor | Starlite/ChEMBL | References |
Homo sapiens | arginine vasopressin receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0146 | 0.4861 | 0.5613 |
Trichomonas vaginalis | set domain proteins, putative | 0.0266 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0093 | 0.2613 | 0.5325 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.2613 | 0.5325 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0053 | 0.5 |
Trypanosoma brucei | polo-like protein kinase | 0.0093 | 0.2613 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0146 | 0.4861 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.4861 | 0.5613 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0093 | 0.2613 | 0.5376 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0093 | 0.2613 | 0.2989 |
Echinococcus multilocularis | acetylcholinesterase | 0.0146 | 0.4861 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.2613 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0146 | 0.4861 | 1 |
Schistosoma mansoni | kinase | 0.0047 | 0.0649 | 0.1239 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2613 | 0.2145 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2613 | 0.2145 |
Brugia malayi | Carboxylesterase family protein | 0.0146 | 0.4861 | 0.5613 |
Brugia malayi | Carboxylesterase family protein | 0.0146 | 0.4861 | 0.5613 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0234 | 0.8618 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2613 | 0.2145 |
Brugia malayi | Pre-SET motif family protein | 0.0234 | 0.8618 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.2613 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2613 | 0.2145 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0093 | 0.2613 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0146 | 0.4861 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0053 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0146 | 0.4861 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.4861 | 0.5613 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0093 | 0.2613 | 0.2574 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2613 | 0.2145 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2613 | 0.2145 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2613 | 0.2145 |
Giardia lamblia | Kinase, PLK | 0.0093 | 0.2613 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0093 | 0.2613 | 0.2989 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0146 | 0.4861 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0093 | 0.2613 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0053 | 0.0109 |
Echinococcus multilocularis | acetylcholinesterase | 0.0146 | 0.4861 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0146 | 0.4861 | 0.5613 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 30 % | Activity at human oxytocin receptor expressed in CHO cells assessed as inhibition of agonist-induced inositol phosphate accumulation at 1 uM | ChEMBL. | 20104850 |
Emax (functional) | = 16 % | Activity at human vasopressin V2 receptor expressed in CHO cells assessed as cAMP accumulation at 1 uM | ChEMBL. | 20104850 |
Ki (binding) | = 170 nM | Displacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells | ChEMBL. | 20104850 |
Ki (binding) | > 1000 nM | Displacement of [3H]AVP from human vasopressin V2 receptor expressed in CHO cells | ChEMBL. | 20104850 |
Ki (binding) | > 5000 nM | Displacement of [3H]AVP from human oxytocin receptor expressed in CHO cells | ChEMBL. | 20104850 |
Kinact (functional) | = 134 nM | Activity at human vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced inositol phosphate accumulation | ChEMBL. | 20104850 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.