Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ap endonuclease | 0.002 | 0.1859 | 0.4231 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.1859 | 0.1859 |
Onchocerca volvulus | Dual oxidase homolog | 0.0079 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.4394 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.1859 | 0.4231 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.4394 | 1 |
Leishmania major | ferric reductase, putative | 0.0037 | 0.4206 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.1859 | 0.4231 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.4394 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.1859 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.1859 | 0.4231 |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.0037 | 0.4206 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0007 | 0.00000022775 | 0.00000051838 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0007 | 0.00000022775 | 0.00000051838 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.4394 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.1859 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.1859 | 0.3413 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4876 | 0.4876 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.1859 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.1859 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.1859 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.4394 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0079 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.4394 | 0.4394 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0007 | 0.00000022775 | 0.00000051838 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0037 | 0.4206 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.4394 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.1859 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.1859 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.1859 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.1859 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.1859 | 0.5 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0037 | 0.4206 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.4394 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.4394 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.1859 | 0.1859 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -38.9 % | Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced IL-6 production at 10 uM by ELISA | ChEMBL. | 21680063 |
Inhibition (functional) | = 8.6 % | Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced IL-6 production at 100 uM by ELISA | ChEMBL. | 21680063 |
Inhibition (functional) | = 11 % | Inhibition of LPS-stimulated COX2 protein expression in mouse J774 cells at 10 uM by chemiluminescence assay | ChEMBL. | 21680063 |
Inhibition (functional) | = 13.4 % | Inhibition of LPS-stimulated iNOS protein expression in mouse J774 cells at 10 uM by RT-PCR analysis | ChEMBL. | 21680063 |
Inhibition (functional) | = 57 % | Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production at 10 uM by Griess reaction | ChEMBL. | 21680063 |
Inhibition (functional) | = 73.4 % | Inhibition of LPS-stimulated COX2 protein expression in mouse J774 cells at 100 uM by chemiluminescence assay | ChEMBL. | 21680063 |
Inhibition (functional) | = 74.6 % | Inhibition of LPS-stimulated iNOS protein expression in mouse J774 cells at 100 uM by RT-PCR analysis | ChEMBL. | 21680063 |
Inhibition (functional) | = 83.7 % | Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production at 100 uM by Griess reaction | ChEMBL. | 21680063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.