Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 3B, cGMP-inhibited | References | |
Homo sapiens | phosphodiesterase 3A, cGMP-inhibited | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | Get druggable targets OG5_132613 | All targets in OG5_132613 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132613 | All targets in OG5_132613 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132613 | All targets in OG5_132613 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glycogen phosphorylase | 0.3939 | 1 | 1 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.1027 | 0.205 | 0.205 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.3939 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.3939 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.3939 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.3939 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.3939 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.3939 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.3939 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.3939 | 1 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.3939 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.3939 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.3939 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.3939 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.3939 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1 | 0.1975 | 0.1975 |
Loa Loa (eye worm) | hypothetical protein | 0.1027 | 0.205 | 0.205 |
Schistosoma mansoni | glycogen phosphorylase | 0.3939 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.3939 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.1703 | 0.3895 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.1703 | 0.3895 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 uM | Inhibition of platelet cAMP phosphodiesterase | ChEMBL. | 2846839 |
IC50 (binding) | = 2 uM | Inhibition of platelet cAMP phosphodiesterase | ChEMBL. | 2846839 |
IC50 (functional) | = 40 uM | Inhibition of ADP induced platelet aggregation | ChEMBL. | 2846839 |
IC50 (functional) | = 40 uM | Inhibition of ADP induced platelet aggregation | ChEMBL. | 2846839 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.