Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0032 | 0.0672 | 0.5735 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.0878 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0084 | 0.2927 | 0.8342 |
Plasmodium falciparum | kinesin-5 | 0.0032 | 0.0672 | 0.5735 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.0878 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0395 | 0.4501 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0084 | 0.2927 | 0.8342 |
Plasmodium vivax | kinesin-5 | 0.0032 | 0.0672 | 0.5735 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0878 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.0878 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0084 | 0.2927 | 0.8342 |
Entamoeba histolytica | kinesin, putative | 0.0032 | 0.0672 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0878 | 1 |
Leishmania major | trypanothione reductase | 0.0037 | 0.0878 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0084 | 0.2927 | 0.8342 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0094 | 0.3333 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.0878 | 1 |
Giardia lamblia | Kinesin-5 | 0.0032 | 0.0672 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.0878 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.0878 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0094 | 0.3333 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 1 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0032 | 0.0672 | 0.5735 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0094 | 0.3333 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0094 | 0.3333 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.8607 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0084 | 0.2927 | 0.8342 |
Brugia malayi | Kinesin motor domain containing protein | 0.0032 | 0.0672 | 0.7655 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.0878 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.0878 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0084 | 0.2927 | 0.8342 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.0878 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.31 uM | Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay | ChEMBL. | 21899292 |
IC50 (functional) | = 0.58 uM | Anticancer activity against human COLO205 cells after 72 hrs by MTS/PMS assay | ChEMBL. | 21899292 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21899292 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.