Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.3866 | 1 | 0.5 |
Toxoplasma gondii | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative | 0.3866 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras | 0.3281 | 0.8474 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0075 | 0.011 | 1 |
Wolbachia endosymbiont of Brugia malayi | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.3866 | 1 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0024 | 0.7399 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0024 | 0.071 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0335 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0161 | 0.0335 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0161 | 0.0335 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0075 | 0.011 | 0.3288 |
Brugia malayi | chromobox protein homolog 3 | 0.0042 | 0.0024 | 0.0432 |
Brugia malayi | Heterochromatin protein 1 | 0.0075 | 0.011 | 0.3087 |
Schistosoma mansoni | chromobox protein | 0.0075 | 0.011 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0045 | 0.0032 | 0.0969 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS | 0.3866 | 1 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0075 | 0.011 | 1 |
Plasmodium vivax | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative | 0.3866 | 1 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0075 | 0.011 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0335 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0054 | 0.162 |
Brugia malayi | Muscleblind-like protein | 0.0161 | 0.0335 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0045 | 0.0032 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.001 | 0.0291 |
Plasmodium falciparum | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.3866 | 1 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0161 | 0.0335 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0054 | 0.162 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0045 | 0.0032 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0054 | 0.1368 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.3866 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0054 | 0.1368 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ALD50 (ADMET) | > 1000 mg kg-1 | Acute toxicity in ip dosed mouse | ChEMBL. | 20163892 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.