Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0556 | 1 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0043 | 0.0146 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0079 | 0.0063 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0043 | 0.0146 | 0.0067 |
Toxoplasma gondii | exonuclease III APE | 0.0043 | 0.0146 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0043 | 0.0146 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0043 | 0.0146 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0556 | 1 | 1 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0079 | 0.024 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0043 | 0.0146 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0335 | 0.1214 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0079 | 0.0063 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0043 | 0.0146 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0079 | 0.024 |
Echinococcus granulosus | kinesin family 1 | 0.0247 | 0.4076 | 0.4029 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0043 | 0.0146 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0043 | 0.0146 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0335 | 0.1214 |
Brugia malayi | hypothetical protein | 0.0173 | 0.2642 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0043 | 0.0146 | 1 |
Onchocerca volvulus | 0.0173 | 0.2642 | 0.5 | |
Echinococcus multilocularis | geminin | 0.0556 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.3459 | 0.3449 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 0.4076 | 0.4029 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0043 | 0.0146 | 0.0067 |
Schistosoma mansoni | ap endonuclease | 0.0043 | 0.0146 | 0.013 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0335 | 0.1214 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0043 | 0.0146 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0043 | 0.0146 | 0.0495 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0043 | 0.0146 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0043 | 0.0146 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0043 | 0.0146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.2642 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0043 | 0.0146 | 0.0495 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0043 | 0.0146 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0335 | 0.1214 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0043 | 0.0146 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0043 | 0.0146 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay | ChEMBL. | 20149654 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.