Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | NADPH oxidoreductase, putative | 0.0166 | 0.1232 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.1232 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.046 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.046 | 1 | 1 |
Trypanosoma brucei | GMP reductase | 0.046 | 1 | 0.5 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.046 | 1 | 1 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.046 | 1 | 0.5 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.046 | 1 | 0.5 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.046 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.046 | 1 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.046 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.1232 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0257 | 0.3948 | 0.2085 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0166 | 0.1232 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.046 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.1232 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.1232 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.1232 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0166 | 0.1232 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.1232 | 1 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.046 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.1232 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.046 | 1 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.046 | 1 | 0.5 |
Onchocerca volvulus | Putative GMP reductase | 0.0203 | 0.2354 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.1232 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.046 | 1 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.046 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.1232 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.046 | 1 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0166 | 0.1232 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.1232 | 1 |
Trypanosoma cruzi | GMP reductase | 0.046 | 1 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0166 | 0.1232 | 1 |
Trypanosoma cruzi | GMP reductase | 0.046 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.1232 | 1 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.046 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.1232 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.1232 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.046 | 1 | 0.5 |
Leishmania major | guanosine monophosphate reductase | 0.046 | 1 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0166 | 0.1232 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after overnight incubation by broth microdilution method | ChEMBL. | 20382539 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.