TDR Targets

Basic information

Technical information

TDR Targets ID: 112863
Name: N-benzyl-N-[(E)-furan-2-ylmethylideneamino]-1 -phenylmethanamine
MW: 290.359 | Formula: C19H18N2O
H donors: 0 H acceptors: 0 LogP: 4.51 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: c1ccc(cc1)CN(Cc1ccccc1)/N=C/c1ccco1
InChi: 1S/C19H18N2O/c1-3-8-17(9-4-1)15-21(16-18-10-5-2-6-11-18)20-14-19-12-7-13-22-19/h1-14H,15-16H2/b20-14+
InChiKey: RESJANLRPGRKLB-XSFVSMFZSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-benzyl-N-[(E)-2-furylmethyleneamino]-1-phenyl-methanamine
N-benzyl-N-[(E)-2-furylmethyleneamino]-1-phenylmethanamine
N-[(E)-furan-2-ylmethylideneamino]-1-phenyl-N-(phenylmethyl)methanamine
dibenzyl-[(E)-2-furfurylideneamino]amine
N-(furan-2-ylmethylideneamino)-1-phenyl-N-(phenylmethyl)methanamine
N-(2-furylmethyleneamino)-1-phenyl-N-(phenylmethyl)methanamine
bis(benzyl)-(2-furylmethyleneamino)amine
AG-690/33078050
BAS 00461934
CBDivE_007417
STOCK1S-03665
N,N-Dibenzyl-N'-furan-2-ylmethylene-hydrazine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucose-6-phosphatase, catalytic subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	conserved hypothetical protein	Get druggable targets OG5_134961	All targets in OG5_134961
Echinococcus multilocularis	conserved hypothetical protein	Get druggable targets OG5_134961	All targets in OG5_134961
Schistosoma mansoni	glucose-6-phosphatase	Get druggable targets OG5_134961	All targets in OG5_134961

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0173	0.194	0.4883
Schistosoma mansoni	phosphatidylserine receptor	0.0016	0.0007	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0017
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0385	0.1985
Brugia malayi	p25-alpha family protein	0.0358	0.4206	1
Schistosoma mansoni	hypothetical protein	0.0104	0.1083	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0017
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0152	0.1672	0.3976
Echinococcus multilocularis	lysine specific demethylase 5A	0.006	0.0549	0.0549
Schistosoma mansoni	jumonji domain containing protein	0.0016	0.0007	0.0018
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0385	0.1985
Echinococcus granulosus	lysine specific demethylase 6a	0.0016	0.0007	0.0038
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.0399	0.095
Schistosoma mansoni	hypothetical protein	0.0048	0.0399	0.1006
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0385	0.0969
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.006	0.0549	0.0549
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.0399	0.2059
Schistosoma mansoni	protein phosphatase 2C	0.0016	0.0007	0.0018
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0016	0.0007	0.0018
Echinococcus multilocularis	geminin	0.0173	0.194	0.194
Echinococcus granulosus	phd:f box containing protein	0.0016	0.0007	0.0038
Schistosoma mansoni	hypothetical protein	0.0048	0.0399	0.1006
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0385	0.0915
Plasmodium vivax	JmjC domain containing protein	0.0016	0.0007	1
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0016	0.0007	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.0399	0.2059
Brugia malayi	jmjC domain containing protein	0.006	0.0549	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1672	0.3976
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0399	0.095
Schistosoma mansoni	glucose-6-phosphatase	0.0339	0.3972	1
Brugia malayi	jmjC domain containing protein	0.006	0.0549	0.1306
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0385	0.0385
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.0399	0.0399
Echinococcus granulosus	geminin	0.0173	0.194	1
Echinococcus multilocularis	GPCR, family 2	0.0048	0.0399	0.0399
Echinococcus multilocularis	lysine specific demethylase 6a	0.0016	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0048	0.0399	0.1006
Echinococcus granulosus	JmjC domain containing protein 4	0.0016	0.0007	0.0038
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.0399	0.095
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0549	0.1383
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.0399	0.095
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0007	0.0017
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.0399	0.0399
Brugia malayi	jmjC domain containing protein	0.0016	0.0007	0.0017
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0007	1
Schistosoma mansoni	hypothetical protein	0.0173	0.194	0.4883
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0152	0.1672	0.3976
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0007	1
Echinococcus multilocularis	conserved hypothetical protein	0.0337	0.3945	0.3945
Brugia malayi	latrophilin 2 splice variant baaae	0.0104	0.1083	0.2576
Loa Loa (eye worm)	hypothetical protein	0.0296	0.344	0.818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1083	0.2576
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0015	0	0.5
Echinococcus granulosus	lysine specific demethylase 5A	0.006	0.0549	0.2832
Schistosoma mansoni	hypothetical protein	0.0048	0.0399	0.1006
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.006	0.0549	0.2832
Echinococcus multilocularis	jumonji domain containing 1A	0.0016	0.0007	0.0007
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0385	0.0385
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0549	0.1306
Brugia malayi	hypothetical protein	0.0296	0.344	0.818
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0007	0.0017
Echinococcus granulosus	jumonji domain containing 1A	0.0016	0.0007	0.0038
Echinococcus multilocularis	phd:f box containing protein	0.0016	0.0007	0.0007
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0549	0.1383
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0016	0.0007	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0385	0.0969
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0016	0.0007	0.0038
Onchocerca volvulus	TPPP family protein homolog	0.0358	0.4206	1
Echinococcus granulosus	GPCR family 2	0.0048	0.0399	0.2059
Leishmania major	hypothetical protein, conserved	0.0016	0.0007	1
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0016	0.0007	1
Schistosoma mansoni	jumonji domain containing protein	0.006	0.0549	0.1383
Brugia malayi	jmjC domain containing protein	0.0016	0.0007	0.0017
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0007	0.0017
Brugia malayi	jmjC domain containing protein	0.0016	0.0007	0.0017
Schistosoma mansoni	phd/f-box containing protein	0.0016	0.0007	0.0018
Loa Loa (eye worm)	p25-alpha family protein	0.0358	0.4206	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0385	0.0915
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0152	0.1672	0.3976
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0385	0.0969
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0016	0.0007	0.0007
Echinococcus multilocularis	JmjC domain containing protein 4	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0017
Brugia malayi	jmjC domain containing protein	0.0016	0.0007	0.0017
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0016	0.0007	1
Echinococcus multilocularis	conserved hypothetical protein	0.0337	0.3945	0.3945

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.1 uM	Compound was evaluated for inhibition of Glucose-6-Phosphatase from Triton X-100 disrupted pig liver microsomes.	ChEMBL.	11514161
IC50 (binding)	= 1.1 uM	Compound was evaluated for inhibition of Glucose-6-Phosphatase from Triton X-100 disrupted pig liver microsomes.	ChEMBL.	11514161

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 6869187

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 112863