Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE AMINOPEPTIDASE PEPC | 0.0074 | 0.2809 | 0.5 |
Schistosoma mansoni | aspartyl aminopeptidase (M18 family) | 0.0074 | 0.2809 | 0.232 |
Entamoeba histolytica | aminopeptidase, putative | 0.0074 | 0.2809 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.2809 | 0.5 |
Plasmodium falciparum | M18 aspartyl aminopeptidase | 0.0074 | 0.2809 | 0.5 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0074 | 0.2809 | 1 |
Trypanosoma cruzi | aspartyl aminopeptidase, putative | 0.0074 | 0.2809 | 0.5 |
Entamoeba histolytica | aspartyl aminopeptidase, putative | 0.0074 | 0.2809 | 1 |
Trypanosoma brucei | aspartyl aminopeptidase, putative | 0.0074 | 0.2809 | 0.5 |
Schistosoma mansoni | aspartyl aminopeptidase (M18 family) | 0.0074 | 0.2809 | 0.232 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 1 | 1 |
Mycobacterium tuberculosis | Probable aminopeptidase PepC | 0.0074 | 0.2809 | 0.5 |
Echinococcus multilocularis | geminin | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | aspartyl aminopeptidase | 0.0074 | 0.2809 | 0.5 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0074 | 0.2809 | 1 |
Leishmania major | aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 | 0.0074 | 0.2809 | 0.5 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0074 | 0.2809 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 1 | 1 |
Plasmodium vivax | M18 aspartyl aminopeptidase, putative | 0.0074 | 0.2809 | 0.5 |
Brugia malayi | Aspartyl aminopeptidase | 0.0074 | 0.2809 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MH, Family M20 | 0.0074 | 0.2809 | 0.5 |
Echinococcus multilocularis | aspartyl aminopeptidase | 0.0074 | 0.2809 | 0.232 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.2809 | 0.5 |
Echinococcus granulosus | aspartyl aminopeptidase | 0.0074 | 0.2809 | 0.232 |
Trypanosoma brucei | aspartyl aminopeptidase, putative | 0.0074 | 0.2809 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.735 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of glucocorticoid receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.2289 uM | PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 61.9995 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.