Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0097 | 0.1571 | 0.5518 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0097 | 0.1571 | 0.5518 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0097 | 0.1571 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0417 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0785 | 0.2419 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0097 | 0.1571 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0097 | 0.1571 | 0.5518 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0417 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0171 | 0.0317 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0097 | 0.1571 | 0.5518 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0241 | 0.5358 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0097 | 0.1571 | 0.1571 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0171 | 0.0317 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0417 | 1 | 0.5 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0097 | 0.1571 | 0.281 |
Loa Loa (eye worm) | acetyltransferase | 0.0141 | 0.2708 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0141 | 0.2708 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0141 | 0.2708 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0241 | 0.5358 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0417 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0417 | 1 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0241 | 0.5358 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0417 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0785 | 0.2419 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0144 | 0.2787 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0084 | 0.1226 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0141 | 0.2708 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0097 | 0.1571 | 0.5518 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0097 | 0.1571 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0241 | 0.5358 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0097 | 0.1571 | 0.5889 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0137 | 0.2604 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0097 | 0.1571 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0241 | 0.5358 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0097 | 0.1571 | 0.5518 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0097 | 0.1571 | 0.1494 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0097 | 0.1571 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 31 uM | Growth inhibition in mouse B16F10 after 3 days by MTT assay | ChEMBL. | 21888390 |
GI50 (functional) | = 42 uM | Growth inhibition in apoptosis-resistant human SK-MEL-28 after 3 days by MTT assay | ChEMBL. | 21888390 |
GI50 (functional) | = 46 uM | Growth inhibition in apoptosis-sensitive human MCF7 after 3 days by MTT assay | ChEMBL. | 21888390 |
GI50 (functional) | = 63 uM | Growth inhibition in apoptosis-resistant human A549 after 3 days by MTT assay | ChEMBL. | 21888390 |
GI50 (functional) | = 72 uM | Growth inhibition in apoptosis-sensitive human PC3 after 3 days by MTT assay | ChEMBL. | 21888390 |
GI50 (functional) | = 77 uM | Growth inhibition in apoptosis-resistant human T98G after 3 days by MTT assay | ChEMBL. | 21888390 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.