Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0901 | 0.2635 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0124 | 0.0248 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0901 | 0.2635 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0901 | 0.2635 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.2398 | 0.7232 | 0.5 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0124 | 0.0248 | 0.5 |
Treponema pallidum | DNA polymerase I (polA) | 0.0124 | 0.0248 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0901 | 0.2635 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0901 | 0.2635 | 0.5 |
Mycobacterium ulcerans | DNA polymerase I | 0.0124 | 0.0248 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0901 | 0.2635 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0901 | 0.2635 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0124 | 0.0248 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0901 | 0.2635 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0124 | 0.0248 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GR (binding) | = 0.8 | GABA ratio (where GABA ratio = IC50 (compound) / IC50 (compound + 10 uM GABA)). | ChEMBL. | 7783151 |
Ki (binding) | = 105 nM | Binding affinity at bovine Benzodiazepine receptor by [3H]-flunitrazepam displacement. | ChEMBL. | 7783151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.