Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.2496 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0247 | 1 | 1 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Trypanosoma brucei | pteridine reductase 1 | 0.0207 | 0.8311 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.007 | 0.2496 | 0.1535 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.007 | 0.2496 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0012 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0012 | 0 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.007 | 0.2496 | 0.2962 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.1236 | 0.0744 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.2496 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.1236 | 0.0744 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.2496 | 1 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0012 | 0 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.007 | 0.2496 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.2496 | 1 |
Leishmania major | pteridine reductase 1 | 0.021 | 0.8428 | 1 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0012 | 0 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.2496 | 0.3003 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.