Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0907 | 0.0907 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0907 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Onchocerca volvulus | 0.0021 | 0.1167 | 0.1544 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0021 | 0.1167 | 0.1167 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.006 | 0.5735 | 0.5735 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Brugia malayi | jmjC domain containing protein | 0.0016 | 0.053 | 0.053 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.006 | 0.5735 | 0.5735 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0021 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.053 | 0.0547 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0907 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0021 | 0.1167 | 0.1167 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0021 | 0.1167 | 0.1167 |
Schistosoma mansoni | nAChR subunit | 0.0021 | 0.1167 | 0.1483 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0021 | 0.1167 | 0.1167 |
Echinococcus multilocularis | phd:f box containing protein | 0.0016 | 0.053 | 0.053 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0021 | 0.1167 | 0.1167 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0021 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0021 | 0.1167 | 0.1205 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0021 | 0.1167 | 0.1167 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0021 | 0.1167 | 0.1167 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0095 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0021 | 0.1167 | 0.1483 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0021 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.9689 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0021 | 0.1167 | 0.1205 |
Brugia malayi | Cation transporter family protein | 0.0021 | 0.1167 | 0.1167 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0021 | 0.1167 | 0.1483 |
Brugia malayi | hypothetical protein | 0.0075 | 0.756 | 0.756 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0907 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0907 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.006 | 0.5735 | 0.5735 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Echinococcus multilocularis | jun protein | 0.0095 | 1 | 1 |
Echinococcus granulosus | jun protein | 0.0095 | 1 | 1 |
Onchocerca volvulus | 0.0075 | 0.756 | 1 | |
Brugia malayi | jmjC domain containing protein | 0.0016 | 0.053 | 0.053 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0907 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0907 | 0.0907 |
Schistosoma mansoni | nAChR subunit | 0.0021 | 0.1167 | 0.1483 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0021 | 0.1167 | 0.1167 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0016 | 0.053 | 0.053 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0907 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0021 | 0.1167 | 0.1167 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0907 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Schistosoma mansoni | nAChR subunit | 0.0021 | 0.1167 | 0.1483 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0021 | 0.1167 | 0.1167 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0907 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0021 | 0.1167 | 0.1483 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0907 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0021 | 0.1167 | 0.1167 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0095 | 1 | 1 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0016 | 0.053 | 0.053 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0021 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0021 | 0.1167 | 0.1205 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0016 | 0.053 | 0.053 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Loa Loa (eye worm) | ACC-1 protein | 0.0021 | 0.1167 | 0.1205 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.053 | 0.0547 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.006 | 0.5735 | 0.5735 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0021 | 0.1167 | 0.1167 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0021 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0021 | 0.1167 | 0.1205 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0021 | 0.1167 | 0.1205 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0907 | 0.5 |
Onchocerca volvulus | 0.0021 | 0.1167 | 0.1544 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.7871 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0907 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0907 | 0.0936 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0016 | 0.053 | 0.053 |
Brugia malayi | jmjC domain containing protein | 0.0016 | 0.053 | 0.053 |
Brugia malayi | Cation transporter family protein | 0.0021 | 0.1167 | 0.1167 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0016 | 0.053 | 0.053 |
Schistosoma mansoni | nAChR subunit | 0.0021 | 0.1167 | 0.1483 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0016 | 0.053 | 0.0547 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0021 | 0.1167 | 0.1167 |
Echinococcus multilocularis | nAChR subunit | 0.0021 | 0.1167 | 0.1167 |
Onchocerca volvulus | Putative nachr subunit | 0.0021 | 0.1167 | 0.1544 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0021 | 0.1167 | 0.1167 |
Schistosoma mansoni | jun-related protein | 0.0077 | 0.7871 | 1 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0021 | 0.1167 | 0.1167 |
Brugia malayi | Cation transporter family protein | 0.0021 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.5735 | 0.5919 |
Schistosoma mansoni | protein phosphatase 2C | 0.0016 | 0.053 | 0.0673 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0021 | 0.1167 | 0.1167 |
Schistosoma mansoni | jumonji domain containing protein | 0.0016 | 0.053 | 0.0673 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0021 | 0.1167 | 0.1167 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0021 | 0.1167 | 0.1167 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0021 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0021 | 0.1167 | 0.1205 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0021 | 0.1167 | 0.1167 |
Brugia malayi | jmjC domain containing protein | 0.0016 | 0.053 | 0.053 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0907 | 0.1152 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0016 | 0.053 | 0.053 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0021 | 0.1167 | 0.1167 |
Echinococcus granulosus | phd:f box containing protein | 0.0016 | 0.053 | 0.053 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0021 | 0.1167 | 0.1167 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0021 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | LGC-31 protein | 0.0021 | 0.1167 | 0.1205 |
Schistosoma mansoni | phd/f-box containing protein | 0.0016 | 0.053 | 0.0673 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.006 | 0.5735 | 0.7286 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0907 | 0.0907 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0021 | 0.1167 | 0.1483 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0021 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0021 | 0.1167 | 0.1167 |
Onchocerca volvulus | 0.0021 | 0.1167 | 0.1544 | |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0016 | 0.053 | 0.0547 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0021 | 0.1167 | 0.1167 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0021 | 0.1167 | 0.1167 |
Brugia malayi | jmjC domain containing protein | 0.006 | 0.5735 | 0.5735 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0021 | 0.1167 | 0.1167 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0021 | 0.1167 | 0.1483 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0021 | 0.1167 | 0.1167 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0021 | 0.1167 | 0.1167 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0907 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0021 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Brugia malayi | jmjC domain containing protein | 0.006 | 0.5735 | 0.5735 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0021 | 0.1167 | 0.1167 |
Onchocerca volvulus | 0.0021 | 0.1167 | 0.1544 | |
Onchocerca volvulus | 0.0021 | 0.1167 | 0.1544 | |
Schistosoma mansoni | phosphatidylserine receptor | 0.0016 | 0.053 | 0.0673 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0016 | 0.053 | 0.053 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0021 | 0.1167 | 0.1167 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0016 | 0.053 | 0.053 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1167 | 0.1205 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0021 | 0.1167 | 0.1167 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0907 | 0.1152 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0016 | 0.053 | 0.0673 |
Loa Loa (eye worm) | ACC-1 protein | 0.0021 | 0.1167 | 0.1205 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0021 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.053 | 0.0547 |
Onchocerca volvulus | 0.0021 | 0.1167 | 0.1544 | |
Schistosoma mansoni | nAChR subunit | 0.0021 | 0.1167 | 0.1483 |
Schistosoma mansoni | nAChR subunit | 0.0021 | 0.1167 | 0.1483 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0016 | 0.053 | 0.0547 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0907 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0021 | 0.1167 | 0.1167 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0907 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.006 | 0.5735 | 0.7286 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0907 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.006 | 0.5735 | 0.7286 |
Echinococcus granulosus | nAChR subunit | 0.0021 | 0.1167 | 0.1167 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0021 | 0.1167 | 0.1167 |
Schistosoma mansoni | nAChR subunit | 0.0021 | 0.1167 | 0.1483 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0021 | 0.1167 | 0.1483 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 20 % | Percent anticonvulsant activity of the compound against pentylenetetrazole (PTZ)-induced attacks at 100 mg/kg peroral dose | ChEMBL. | 12477354 |
Activity (functional) | = 20 % | Percent anticonvulsant activity of the compound against pentylenetetrazole (PTZ)-induced attacks at 100 mg/kg peroral dose | ChEMBL. | 12477354 |
Activity (functional) | = 107 % | Anxiolytic activity in mice using light-dark box and % time spent in light was reported at 100 mg/kg peroral dose | ChEMBL. | 12477354 |
Activity (functional) | = 107 % | Anxiolytic activity in mice using light-dark box and % time spent in light was reported at 100 mg/kg peroral dose | ChEMBL. | 12477354 |
Activity (functional) | = 154.8 % | Anxiolytic activity in mice using light-dark box and % time spent in light was reported at 30 mg/kg peroral dose | ChEMBL. | 12477354 |
Activity (functional) | = 154.8 % | Anxiolytic activity in mice using light-dark box and % time spent in light was reported at 30 mg/kg peroral dose | ChEMBL. | 12477354 |
Atttacks (functional) | = 14.2 % | Anticonvulsant activity against PTZ induced atacks at 100 mg/kg dose Flumazenil and 0.3 mg/kg Diazepam | ChEMBL. | 10377227 |
Atttacks (functional) | = 14.2 % | Anticonvulsant activity against PTZ induced atacks at 100 mg/kg dose Flumazenil and 0.3 mg/kg Diazepam | ChEMBL. | 10377227 |
No. of crosses (functional) | = 18.6 | Antianxiety activity was measured based on light/dark box thus calculated no of crosses of mice at 100 mg/kg dose Flumazenil and 1 mg/kg Diazepam | ChEMBL. | 10377227 |
No. of falls (functional) | = 0.4 | Motor coordination of mouse as number of falls in 30 sec was reported after 100 mg/kg peroral dose using rotorod test | ChEMBL. | 12477354 |
No. of falls (functional) | = 0.46 | Muscle relaxant effect measured by rota-rod test at 100 mg/kg dose Flumazenil and 0.3 mg/kg Diazepam | ChEMBL. | 10377227 |
No. of transfers (functional) | = 15.6 | Anxiolytic activity in mice using light-dark box and no. of transfers between compartments were reported at 100 mg/kg peroral dose | ChEMBL. | 12477354 |
No. of transfers (functional) | = 23 | Anxiolytic activity in mice using light-dark box and no. of transfers between compartments were reported at 30 mg/kg peroral dose | ChEMBL. | 12477354 |
Time in flight (functional) | = 104.1 % | Antianxiety activity was measured based on light/dark box thus calculated % time in light of mice at 100 mg/kg dose Flumazenil and 1 mg/kg Diazepam | ChEMBL. | 10377227 |
Time in flight (functional) | = 104.1 % | Antianxiety activity was measured based on light/dark box thus calculated % time in light of mice at 100 mg/kg dose Flumazenil and 1 mg/kg Diazepam | ChEMBL. | 10377227 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.