Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.8823 | 0 | 0.5 |
Trypanosoma brucei | squalene synthase, putative | 0.8995 | 1 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.8995 | 1 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.8995 | 1 | 0.5 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.8823 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Solubility | Insoluble 0 | Solubility of the compound was determined; INS= less than 0.1 | ChEMBL. | 3783577 |
Survivors at day 4 (functional) | = 5 | Compound was tested for antitumor activity in P-388 lymphocytic leukemia system at 400 mg/kg dose levels per injection; 5/6 | ChEMBL. | 3783577 |
Survivors at day 4 (functional) | = 6 | Antitumor activity in P-388 lymphocytic leukemia system at 200 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Survivors at day 4 (functional) | = 6 | Antitumor activity in P-388 lymphocytic leukemia system at 100 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Survivors at day 4 (functional) | = 6 | Antitumor activity in P-388 lymphocytic leukemia system at 50 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Survivors at day 4 (functional) | = 6 | Antitumor activity in P-388 lymphocytic leukemia system at 25 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
T/C (functional) | = 102 % | Antitumor activity in P-388 lymphocytic leukemia system at 50 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
T/C (functional) | = 102 % | Antitumor activity in P-388 lymphocytic leukemia system at 50 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
T/C (functional) | = 103 % | Compound was tested for antitumor activity in P-388 lymphocytic leukemia system at 25 mg/kg dose levels per injection | ChEMBL. | 3783577 |
T/C (functional) | = 103 % | Compound was tested for antitumor activity in P-388 lymphocytic leukemia system at 25 mg/kg dose levels per injection | ChEMBL. | 3783577 |
T/C (functional) | = 111 % | Compound was tested for antitumor activity in P-388 lymphocytic leukemia system . at 400 mg/kg dose levels per injection | ChEMBL. | 3783577 |
T/C (functional) | = 111 % | Antitumor activity in P-388 lymphocytic leukemia system at 50 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
T/C (functional) | = 111 % | Compound was tested for antitumor activity in P-388 lymphocytic leukemia system . at 400 mg/kg dose levels per injection | ChEMBL. | 3783577 |
T/C (functional) | = 111 % | Antitumor activity in P-388 lymphocytic leukemia system at 50 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
T/C (functional) | = 116 % | Antitumor activity in P-388 lymphocytic leukemia system at 100 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
T/C (functional) | = 116 % | Antitumor activity in P-388 lymphocytic leukemia system at 100 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
T/C (functional) | = 117 % | Antitumor activity in P-388 lymphocytic leukemia system at 100 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
T/C (functional) | = 117 % | Antitumor activity in P-388 lymphocytic leukemia system at 100 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
T/C (functional) | = 125 % | Antitumor activity in P-388 lymphocytic leukemia system at 200 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
T/C (functional) | = 125 % | Antitumor activity in P-388 lymphocytic leukemia system at 200 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
T/C (functional) | = 139 % | Antitumor activity in P-388 lymphocytic leukemia system at 200 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
T/C (functional) | = 139 % | Antitumor activity in P-388 lymphocytic leukemia system at 200 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = -1 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight was calculated at 50 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = -1 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight was calculated at 50 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = -0.9 g | Compound was tested for antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight was calculated at 400 mg/kg dose levels per injection | ChEMBL. | 3783577 |
Weight difference (functional) | = -0.9 g | Compound was tested for antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight was calculated at 400 mg/kg dose levels per injection | ChEMBL. | 3783577 |
Weight difference (functional) | = -0.8 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight calculated at 100 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = -0.8 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight calculated at 100 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = -0.7 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight was calculated at 200 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = -0.7 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight was calculated at 200 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = -0.6 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight was calculated at 200 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = -0.6 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight was calculated at 200 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = -0.5 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight was calculated at 50 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = -0.5 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight was calculated at 50 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = -0.4 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight calculated at 100 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = -0.4 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight calculated at 100 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = 0 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight was calculated at 25 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Weight difference (functional) | = 0 g | Antitumor activity in P-388 lymphocytic leukemia system and the difference in body weight was calculated at 25 mg/kg dose levels per injection. | ChEMBL. | 3783577 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.