Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | CAAX prenyl protease 2 | 0.009 | 0.4944 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0117 | 0.6787 | 0.8828 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.2253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.4944 | 0.9382 |
Onchocerca volvulus | 0.0093 | 0.5121 | 1 | |
Brugia malayi | CAAX amino terminal protease family protein | 0.009 | 0.4944 | 0.9382 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.5121 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.2253 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0019 | 0 | 0.5 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.009 | 0.4944 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.2253 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.2253 | 0.2931 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0117 | 0.6787 | 0.8828 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.009 | 0.4944 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0117 | 0.6787 | 0.8828 |
Mycobacterium ulcerans | hypothetical protein | 0.0019 | 0 | 0.5 |
Chlamydia trachomatis | hypothetical protein | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.009 | 0.4944 | 1 |
Entamoeba histolytica | CAAX prenyl protease family | 0.009 | 0.4944 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0093 | 0.5121 | 0.035 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.2253 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.013 | 0.7688 | 1 |
Treponema pallidum | hypothetical protein | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.009 | 0.4944 | 0.5 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.009 | 0.4944 | 1 |
Giardia lamblia | Hypothetical protein | 0.009 | 0.4944 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.013 | 0.7688 | 1 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.009 | 0.4944 | 1 |
Mycobacterium ulcerans | integral membrane protein | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.013 | 0.7688 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0117 | 0.6787 | 0.8828 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0117 | 0.6787 | 0.8828 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.013 | 0.7688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.5121 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0093 | 0.5121 | 0.035 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0117 | 0.6787 | 0.8828 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.2253 | 1 |
Brugia malayi | Trypsin family protein | 0.0093 | 0.5121 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.