Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.0162 | 0.0545 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0162 | 0.0545 | 0.5 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.1088 | 1 | 1 |
Trypanosoma brucei | beta lactamase | 0.0522 | 0.422 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0189 | 0.0813 | 0.5 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0522 | 0.422 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0189 | 0.0813 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0189 | 0.0813 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0189 | 0.0813 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0189 | 0.0813 | 0.5 |
Onchocerca volvulus | 0.0109 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ILSmax (functional) | = 44 | Maximum increase in life span was determined against P388 leukemia at 4-5 doses of compound | ChEMBL. | 3681888 |
MTD (functional) | = 15 uM kg-1 | Maximally tolerated dose was measured after ip administration of compound, 24 hr after tumor implantation. | ChEMBL. | 3681888 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.