TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 518.518 | Formula: C28H37Cl2N3O2
H donors: 0 H acceptors: 2 LogP: 5.47 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CCN(C(=O)C1CCCN(C1)CCC(c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)CC
InChi: 1S/C28H37Cl2N3O2/c1-4-33(5-2)28(35)24-12-9-16-32(20-24)17-15-23(22-13-14-25(29)26(30)18-22)19-31(3)27(34)21-10-7-6-8-11-21/h6-8,10-11,13-14,18,23-24H,4-5,9,12,15-17,19-20H2,1-3H3
InChiKey: CWPYEAPHWBNCJQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0059	0.0415	0.1338
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0415	0.0415
Echinococcus multilocularis	neuropeptides capa receptor	0.0059	0.0415	0.0415
Schistosoma mansoni	hypothetical protein	0.0059	0.0415	0.1321
Brugia malayi	ORL1-like opioid receptor	0.0059	0.0415	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Brugia malayi	Dopamine receptor protein 1	0.0059	0.0415	0.1338
Schistosoma mansoni	hypothetical protein	0.0059	0.0415	0.1321
Brugia malayi	larval opioid receptor	0.0059	0.0415	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0094	0.0847	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0059	0.0415	0.0415
Echinococcus granulosus	neuropeptide receptor	0.0059	0.0415	0.1212
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0415	0.1212
Schistosoma mansoni	myosin xvIII	0.0059	0.0415	0.1321
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0059	0.0415	0.1212
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0059	0.0415	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Leishmania major	cathepsin L-like protease	0.0071	0.0562	0.663
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0059	0.0415	0.1212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0415	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0476	0.1387
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.0562	0.181
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Brugia malayi	TAR-binding protein	0.0064	0.0483	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0059	0.0415	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Echinococcus granulosus	neuropeptide Y receptor	0.0059	0.0415	0.1212
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0059	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Entamoeba histolytica	cysteine protease, putative	0.0025	0	0.5
Schistosoma mansoni	amine GPCR	0.0059	0.0415	0.1321
Echinococcus granulosus	fmrfamide receptor	0.0059	0.0415	0.1212
Schistosoma mansoni	hypothetical protein	0.0059	0.0415	0.1321
Brugia malayi	hypothetical protein	0.0059	0.0415	0.1338
Onchocerca volvulus		0.0059	0.0415	1
Echinococcus multilocularis	serotonin receptor	0.0059	0.0415	0.0415
Echinococcus granulosus	somatostatin receptor	0.0059	0.0415	0.1212
Brugia malayi	putative neuropeptide receptor NPR1	0.0059	0.0415	0.1338
Echinococcus multilocularis	somatostatin receptor	0.0059	0.0415	0.0415
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0415	0.0415
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.0562	0.181
Echinococcus granulosus	serotonin receptor	0.0059	0.0415	0.1212
Brugia malayi	Serotonin receptor	0.0059	0.0415	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Echinococcus multilocularis	cathepsin b	0.028	0.3104	0.3104
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0094	0.0847	0.273
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0483	0.1536
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0	0.5
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0307	0.3428	0.3428
Schistosoma mansoni	histamine h1 receptor	0.0059	0.0415	0.1321
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0307	0.3428	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Brugia malayi	follicle stimulating hormone receptor	0.0059	0.0415	0.1338
Echinococcus multilocularis	dro:myosuppressin receptor	0.0059	0.0415	0.0415
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0415	0.0415
Brugia malayi	G protein-coupled receptor	0.0059	0.0415	0.1338
Echinococcus multilocularis	fmrfamide receptor	0.0059	0.0415	0.0415
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0059	0.0415	0.0415
Echinococcus granulosus	hypothetical protein	0.0059	0.0415	0.1212
Brugia malayi	hypothetical protein	0.0059	0.0415	0.1338
Echinococcus granulosus	tm gpcr rhodopsin	0.0059	0.0415	0.1212
Onchocerca volvulus		0.0059	0.0415	1
Onchocerca volvulus		0.0059	0.0415	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0059	0.0415	0.1212
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0059	0.0415	1
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0	0.5
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0209	0.2237	0.2237
Schistosoma mansoni	neuropeptide F-like receptor	0.0059	0.0415	0.1321
Echinococcus multilocularis	g protein coupled receptor	0.0059	0.0415	0.0415
Onchocerca volvulus		0.0059	0.0415	1
Echinococcus multilocularis	neuropeptide receptor	0.0059	0.0415	0.0415
Schistosoma mansoni	biogenic amine receptor	0.0059	0.0415	0.1321
Echinococcus granulosus	sex peptide receptor	0.0059	0.0415	0.1212
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0094	0.0847	1
Brugia malayi	RE15519p	0.0059	0.0415	0.1338
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0483	0.1536
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Echinococcus granulosus	neuropeptide FF receptor 2	0.0059	0.0415	0.1212
Schistosoma mansoni	metabotropic glutamate receptor	0.0209	0.2237	0.7115
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Schistosoma mansoni	neuropeptide F-like receptor	0.0059	0.0415	0.1321
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.028	0.3104	0.9874
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0059	0.0415	0.0415
Brugia malayi	Receptor family ligand binding region containing protein	0.0064	0.0476	0.1532
Echinococcus granulosus	dro:myosuppressin receptor	0.0059	0.0415	0.1212
Echinococcus multilocularis	g protein coupled receptor	0.0059	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Schistosoma mansoni	biogenic amine receptor	0.0059	0.0415	0.1321
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0415	0.1321
Onchocerca volvulus		0.0059	0.0415	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0415	0.1212
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0415	0.1212
Brugia malayi	hypothetical protein	0.0059	0.0415	0.1338
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0059	0.0415	0.1321
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0059	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Onchocerca volvulus	Poor gastrulation protein homolog	0.004	0.0191	0.4591
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0059	0.0415	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Brugia malayi	putative neuropeptide receptor	0.0059	0.0415	0.1338
Schistosoma mansoni	hypothetical protein	0.0059	0.0415	0.1321
Onchocerca volvulus		0.0059	0.0415	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0249	0.2728	0.879
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0059	0.0415	0.0415
Loa Loa (eye worm)	neuropeptide F receptor	0.0059	0.0415	0.1212
Brugia malayi	sulfakinin receptor protein	0.0059	0.0415	0.1338
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0059	0.0415	0.1212
Echinococcus multilocularis	neuropeptide Y receptor	0.0059	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0059	0.0415	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Brugia malayi	G-protein coupled receptor	0.0059	0.0415	0.1338
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0415	0.0415
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0415	0.1212
Brugia malayi	RNA binding protein	0.0064	0.0483	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Echinococcus granulosus	allatostatin A receptor	0.0059	0.0415	0.1212
Echinococcus granulosus	cathepsin b	0.028	0.3104	0.9053
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0415	0.1212
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.0562	0.181
Trypanosoma cruzi	cruzipain precursor, putative	0.0071	0.0562	0.181
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0059	0.0415	0.0415
Brugia malayi	hypothetical protein	0.0059	0.0415	0.1338
Loa Loa (eye worm)	hypothetical protein	0.028	0.3104	0.9053
Echinococcus multilocularis	serotonin receptor	0.0059	0.0415	0.0415
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0483	0.1536
Onchocerca volvulus		0.0059	0.0415	1
Brugia malayi	metabotropic glutamate receptor type 2	0.0121	0.1176	0.3787
Onchocerca volvulus		0.0059	0.0415	1
Brugia malayi	neuropeptide F receptor	0.0059	0.0415	0.1338
Loa Loa (eye worm)	neuropeptide F receptor	0.0059	0.0415	0.1212
Schistosoma mansoni	adenoreceptor	0.0059	0.0415	0.1321
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0059	0.0415	0.0415
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0025	0	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0059	0.0415	0.1338
Brugia malayi	GnHR receptor homolog	0.0059	0.0415	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0352
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0059	0.0415	0.1321
Echinococcus multilocularis	neuropeptide s receptor	0.0059	0.0415	0.0415
Echinococcus multilocularis	neuropeptide receptor	0.0059	0.0415	0.0415
Echinococcus multilocularis	cathepsin b	0.028	0.3104	0.3104
Brugia malayi	neuropeptide F receptor	0.0059	0.0415	0.1338
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0059	0.0415	0.1338
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0483	0.1408
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0059	0.0415	0.1321
Schistosoma mansoni	hypothetical protein	0.0035	0.0121	0.0384
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Onchocerca volvulus		0.0059	0.0415	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.028	0.3104	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Echinococcus granulosus	neuropeptide s receptor	0.0059	0.0415	0.1212
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0059	0.0415	0.0415
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0483	0.1408
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0059	0.0415	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0059	0.0415	0.1338
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0059	0.0415	0.1321
Loa Loa (eye worm)	glutamate receptor	0.0249	0.2728	0.7958
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0059	0.0415	0.1321
Echinococcus granulosus	neuropeptides capa receptor	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Onchocerca volvulus		0.0059	0.0415	1
Echinococcus granulosus	neuropeptide Y receptor	0.0059	0.0415	0.1212
Brugia malayi	G protein-coupled receptor F59B2.13	0.0059	0.0415	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.004	0.0191	0.0614
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.028	0.3104	0.9874
Schistosoma mansoni	opsin-like receptor	0.0059	0.0415	0.1321
Echinococcus multilocularis	GPCR, family 3, C terminal	0.004	0.0191	0.0191
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0483	0.1556
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0121	0.0389
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0059	0.0415	0.1212
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0059	0.0415	0.1321
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0059	0.0415	0.0415
Toxoplasma gondii	cathepsin B	0.0094	0.0847	1
Brugia malayi	AKH receptor	0.0059	0.0415	0.1338
Echinococcus granulosus	neuropeptide receptor	0.0059	0.0415	0.1212
Brugia malayi	Dopamine receptor	0.0059	0.0415	0.1338
Plasmodium vivax	vivapain-2	0.0025	0	0.5
Loa Loa (eye worm)	cathepsin B	0.0094	0.0847	0.2472
Giardia lamblia	Cathepsin B precursor	0.0094	0.0847	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0415	0.0415
Schistosoma mansoni	amine GPCR	0.0059	0.0415	0.1321
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0059	0.0415	0.1321
Echinococcus granulosus	7TM GPCR rhodopsin	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0059	0.0415	0.1212
Onchocerca volvulus		0.0059	0.0415	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0059	0.0415	0.1321
Schistosoma mansoni	neuropeptide receptor	0.0059	0.0415	0.1321
Schistosoma mansoni	opsin-like receptor	0.0059	0.0415	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Brugia malayi	hypothetical protein	0.0059	0.0415	0.1338
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0226	0.2444	0.7873
Schistosoma mansoni	growth hormone secretagogue receptor	0.0059	0.0415	0.1321
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0064	0.0476	0.1387
Brugia malayi	Melatonin receptor type 1A	0.0059	0.0415	0.1338
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0415	0.1321
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0415	0.0415
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0483	0.1536
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0415	0.1321
Echinococcus multilocularis	g protein coupled receptor	0.0059	0.0415	0.0415
Brugia malayi	G-protein coupled receptor	0.0059	0.0415	0.1338
Loa Loa (eye worm)	TYRA-2 protein	0.0059	0.0415	0.1212
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0094	0.0847	0.2696
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0059	0.0415	0.1212
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.004	0.0191	0.0556
Schistosoma mansoni	neuropeptide receptor	0.0059	0.0415	0.1321
Loa Loa (eye worm)	glutamate receptor	0.0098	0.0891	0.2598
Onchocerca volvulus		0.0059	0.0415	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0415	0.1321
Echinococcus granulosus	g protein coupled receptor	0.0059	0.0415	0.1212
Brugia malayi	hypothetical protein	0.0059	0.0415	0.1338
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0059	0.0415	0.0415
Schistosoma mansoni	biogenic amine receptor	0.0059	0.0415	0.1321
Brugia malayi	cathepsin B-like cysteine proteinase	0.028	0.3104	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0316	0.0921
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0209	0.2237	0.6524
Schistosoma mansoni	neuropeptide receptor	0.0059	0.0415	0.1321
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0059	0.0415	0.0415
Loa Loa (eye worm)	G-protein coupled receptor	0.0059	0.0415	0.1212
Leishmania major	cathepsin L-like protease	0.0071	0.0562	0.663
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0483	0.1408
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0094	0.0847	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0059	0.0415	0.1212
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0059	0.0415	0.1212
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.028	0.3104	0.9874
Trypanosoma cruzi	major cysteine proteinase, putative	0.0058	0.0399	0.1285
Onchocerca volvulus		0.0059	0.0415	1
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0307	0.3428	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0059	0.0415	0.1212
Echinococcus granulosus	g-protein coupled receptor	0.0059	0.0415	0.1212
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0316	0.1018
Echinococcus multilocularis	g-protein coupled receptor	0.0059	0.0415	0.0415
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0059	0.0415	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Schistosoma mansoni	amine GPCR	0.0059	0.0415	0.1321
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0483	0.1536
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Echinococcus granulosus	GPCR family 3 C terminal	0.004	0.0191	0.0556
Echinococcus granulosus	7tm_1 domain containing protein	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Echinococcus granulosus	g protein coupled receptor	0.0059	0.0415	0.1212
Leishmania major	cathepsin L-like protease	0.0071	0.0562	0.663
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0059	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0415	0.1321
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0059	0.0415	0.1321
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0059	0.0415	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0059	0.0415	0.1321
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0415	0.1321
Echinococcus granulosus	tm gpcr rhodopsin	0.0059	0.0415	0.1212
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0059	0.0415	0.0415
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0059	0.0415	0.1212
Echinococcus multilocularis	sex peptide receptor	0.0059	0.0415	0.0415
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0316	0.1018
Echinococcus granulosus	neuropeptides capa receptor	0.0059	0.0415	0.1212
Echinococcus multilocularis	G protein coupled receptor 139	0.0059	0.0415	0.0415
Echinococcus multilocularis	allatostatin A receptor	0.0059	0.0415	0.0415
Onchocerca volvulus		0.0059	0.0415	1
Brugia malayi	hypothetical protein	0.0059	0.0415	0.1338
Echinococcus multilocularis	orexin receptor type 2	0.0059	0.0415	0.0415
Loa Loa (eye worm)	melatonin receptor type 1A	0.0059	0.0415	0.1212
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.028	0.3104	0.9874
Onchocerca volvulus		0.0059	0.0415	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0415	0.1212
Echinococcus multilocularis	neuropeptides capa receptor	0.0059	0.0415	0.0415
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0415	0.1321
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0415	0.0415
Echinococcus granulosus	tm gpcr rhodopsin	0.0059	0.0415	0.1212
Schistosoma mansoni	amine GPCR	0.0059	0.0415	0.1321
Schistosoma mansoni	metabotropic glutamate receptor	0.0121	0.1176	0.374
Onchocerca volvulus	Metabotropic glutamate receptor homolog	0.004	0.0191	0.4591
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0059	0.0415	0.0415
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0064	0.0476	0.1387
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0066	0.0496	0.1597
Brugia malayi	Dopamine receptor protein 2	0.0059	0.0415	0.1338
Giardia lamblia	Cathepsin B precursor	0.0094	0.0847	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0059	0.0415	0.0415
Echinococcus granulosus	biogenic amine 5HT receptor	0.0059	0.0415	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Echinococcus granulosus	cathepsin b	0.028	0.3104	0.9053
Schistosoma mansoni	neuropeptide receptor	0.0059	0.0415	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0025	0	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0059	0.0415	0.1212
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0059	0.0415	0.0415
Onchocerca volvulus		0.0059	0.0415	1
Giardia lamblia	Cathepsin B precursor	0.0094	0.0847	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0059	0.0415	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0316	0.0921
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0025	0	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0059	0.0415	0.0415
Plasmodium vivax	vivapain-2	0.0025	0	0.5
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0283	0.3144	1
Schistosoma mansoni	amine GPCR	0.0059	0.0415	0.1321
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0059	0.0415	0.1212
Echinococcus granulosus	neuropeptide receptor A26	0.0059	0.0415	0.1212
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0483	0.1408
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0059	0.0415	0.1321
Schistosoma mansoni	opsin-like receptor	0.0059	0.0415	0.1321
Brugia malayi	hypothetical protein	0.0059	0.0415	0.1338
Onchocerca volvulus		0.0059	0.0415	1
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0483	0.0483
Schistosoma mansoni	hypothetical protein	0.004	0.0191	0.0607
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0059	0.0415	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Echinococcus multilocularis	neuropeptide receptor A26	0.0059	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0415	0.1212
Brugia malayi	Serotonin receptor	0.0059	0.0415	0.1338
Brugia malayi	hypothetical protein	0.0059	0.0415	0.1338
Schistosoma mansoni	neuropeptide f receptor 76f	0.0059	0.0415	0.1321
Echinococcus granulosus	g protein coupled receptor	0.0059	0.0415	0.1212
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0059	0.0415	0.1212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0415	0.1321
Echinococcus granulosus	orexin receptor type 2	0.0059	0.0415	0.1212

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 61 %	Binding affinity towards human tachykinin receptor 2 using [125I]- NKA radioligand expressed in rat duodenum at 100 nM	ChEMBL.	12798336
Inhibition (binding)	= 61 %	Binding affinity towards human tachykinin receptor 2 using [125I]- NKA radioligand expressed in rat duodenum at 100 nM	ChEMBL.	12798336

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 114200