Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pyruvate kinase | 0.0213 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0213 | 1 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0213 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0213 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0213 | 1 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0213 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0213 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0213 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0213 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0213 | 1 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0213 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0213 | 1 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0213 | 1 | 0.5 |
Leishmania major | pyruvate kinase | 0.0213 | 1 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0213 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0213 | 1 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0213 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0213 | 1 | 0.5 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0148 | 0.5661 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0213 | 1 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0213 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0213 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0213 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.0213 | 1 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0213 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0213 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0168 | 0.6979 | 0.5671 |
Loa Loa (eye worm) | pyruvate kinase | 0.0213 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.0213 | 1 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0213 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0213 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.