Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 21.86 uM | Inhibition of human aromatase preincubated with NADP+ for 10 mins before substrate addition measured after 30 mins | ChEMBL. | 20558073 |
Inhibition (binding) | = 77.6 % | Inhibition of human aromatase at 20 ug/ml preincubated with NADP+ for 10 mins before substrate addition measured after 30 mins | ChEMBL. | 20558073 |
Km (binding) | = 2.19 uM | Inhibition of human aromatase at IC50 concentration preincubated with NADP+ for 10 mins before substrate addition measured after 30 mins | ChEMBL. | 20558073 |
Vmax (binding) | = 34.9 pmol/min | Inhibition of human aromatase assessed per mg of protein at IC50 concentration preincubated with NADP+ for 10 mins before substrate addition measured after 30 mins | ChEMBL. | 20558073 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.