Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | calcium dependent protein kinase | 0.0061 | 0.0297 | 0.0266 |
Echinococcus multilocularis | insulin receptor | 0.0048 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0151 | 0.2212 | 0.2576 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0151 | 0.2212 | 0.2212 |
Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0448 | 0.8496 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0081 | 0.073 | 0.07 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK3 | 0.0071 | 0.0512 | 0.5 |
Plasmodium vivax | calcium-dependent protein kinase 1, putative | 0.0071 | 0.0512 | 0.5 |
Trypanosoma brucei | calcium/calmodulin-dependent protein kinase, putative | 0.0071 | 0.0512 | 0.5 |
Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0071 | 0.0512 | 0.0567 |
Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase subunit type II alpha | 0.0448 | 0.8496 | 1 |
Plasmodium vivax | calcium-dependent protein kinase 3, putative | 0.0071 | 0.0512 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0048 | 0.0032 | 0.0032 |
Entamoeba histolytica | protein kinase, putative | 0.0071 | 0.0512 | 0.5 |
Plasmodium falciparum | calcium-dependent protein kinase 1 | 0.0071 | 0.0512 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type 1 | 0.0071 | 0.0512 | 0.0482 |
Schistosoma mansoni | protein kinase | 0.0519 | 1 | 1 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK2A | 0.0071 | 0.0512 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0081 | 0.073 | 0.07 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0071 | 0.0512 | 0.0512 |
Plasmodium falciparum | calcium-dependent protein kinase 5 | 0.0071 | 0.0512 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0519 | 1 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0071 | 0.0512 | 0.0512 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0151 | 0.2212 | 0.2187 |
Echinococcus multilocularis | calcium dependent protein kinase | 0.0061 | 0.0297 | 0.0297 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0071 | 0.0512 | 0.0482 |
Entamoeba histolytica | protein kinase, putative | 0.0071 | 0.0512 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0519 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0712 | 0.0682 |
Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase ID | 0.0071 | 0.0512 | 0.0567 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0712 | 0.0682 |
Schistosoma mansoni | tyrosine kinase | 0.0081 | 0.073 | 0.07 |
Plasmodium falciparum | calcium-dependent protein kinase 4 | 0.0071 | 0.0512 | 0.5 |
Brugia malayi | Cam kinase protein 1 | 0.0071 | 0.0512 | 0.0567 |
Plasmodium falciparum | calcium-dependent protein kinase 2 | 0.0071 | 0.0512 | 0.5 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK2B | 0.0071 | 0.0512 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0071 | 0.0512 | 0.0512 |
Loa Loa (eye worm) | CAMK/CAMK2 protein kinase | 0.0071 | 0.0512 | 0.0567 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0071 | 0.0512 | 0.0482 |
Leishmania major | protein kinase, putative | 0.0071 | 0.0512 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0151 | 0.2212 | 0.2187 |
Schistosoma mansoni | protein kinase | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0512 | 0.0567 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0712 | 0.0682 |
Plasmodium falciparum | calcium-dependent protein kinase 3 | 0.0071 | 0.0512 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0081 | 0.073 | 0.07 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0081 | 0.073 | 0.073 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0071 | 0.0512 | 0.0482 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0151 | 0.2212 | 0.2576 |
Plasmodium vivax | calcium-dependent protein kinase, putative | 0.0071 | 0.0512 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0071 | 0.0512 | 0.5 |
Plasmodium vivax | calcium-dependent protein kinase 4, putative | 0.0071 | 0.0512 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.000000075 M | Effective dose for differentiation -inducing activity against human promyelotic leukemia cells | ChEMBL. | 3184125 |
ED50 (functional) | = 0.000000075 M | Effective dose for differentiation -inducing activity against human promyelotic leukemia cells | ChEMBL. | 3184125 |
Ratio (functional) | = 0.037 | Ratio of the ED50 of compound to that of ED50 of retinoic acid, expressed as relative activity | ChEMBL. | 3184125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.