Detailed information for compound 1146435

Basic information

Technical information
  • TDR Targets ID: 1146435
  • Name: 1-phenyl-4-[4-(3-phenyl-1,2-oxazol-5-yl)butyl ]piperazine
  • MW: 361.48 | Formula: C23H27N3O
  • H donors: 0 H acceptors: 1 LogP: 4.67 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)N1CCN(CC1)CCCCc1onc(c1)c1ccccc1
  • InChi: 1S/C23H27N3O/c1-3-9-20(10-4-1)23-19-22(27-24-23)13-7-8-14-25-15-17-26(18-16-25)21-11-5-2-6-12-21/h1-6,9-12,19H,7-8,13-18H2
  • InChiKey: MPRVFPKBKLXAAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-phenyl-4-[4-(3-phenylisoxazol-5-yl)butyl]piperazine
  • 1-phenyl-4-[4-(3-phenyl-5-isoxazolyl)butyl]piperazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0048 0.3012 0.3012
Leishmania major mitochondrial import inner membrane translocase subunit tim17, putative,inner membrane preprotein translocase Tim17, putative 0.0004 0 0.5
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.2516 0.8354
Leishmania major peroxisomal membrane protein 4, putative 0.0004 0 0.5
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.2516 0.2516
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.3012 1
Loa Loa (eye worm) hypothetical protein 0.004 0.2516 0.2516
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.2516 0.8354
Trypanosoma cruzi peroxisomal membrane protein 4, putative 0.0004 0 0.5
Brugia malayi hypothetical protein 0.0036 0.2246 0.2246
Schistosoma mansoni hypothetical protein 0.004 0.2516 0.8354
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.2516 0.2516
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0048 0.3012 0.3012
Trypanosoma cruzi mitochondrial import inner membrane translocase subunit TIM17, putative 0.0004 0 0.5
Onchocerca volvulus Putative mitochondrial import inner membrane translocase subunit tim17 0.0004 0 0.5
Brugia malayi hypothetical protein 0.0036 0.2246 0.2246
Trypanosoma brucei mitochondrial import inner membrane translocase subunit tim17 0.0004 0 0.5
Echinococcus granulosus expressed protein 0.0048 0.3012 0.3012
Trypanosoma brucei peroxisomal membrane protein 4, putative 0.0004 0 0.5
Trichomonas vaginalis hypothetical protein 0.0004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0149 1 1
Trypanosoma cruzi mitochondrial import inner membrane translocase subunit TIM17, putative 0.0004 0 0.5
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.2516 0.2516
Echinococcus multilocularis expressed protein 0.0048 0.3012 0.3012
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.3012 1
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.3012 1
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0048 0.3012 1
Trichomonas vaginalis conserved hypothetical protein 0.0004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0149 1 1
Trypanosoma cruzi peroxisomal membrane protein 4, putative 0.0004 0 0.5
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.2516 0.8354
Echinococcus multilocularis muscleblind protein 1 0.0149 1 1
Echinococcus multilocularis muscleblind protein 0.0149 1 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.2516 0.2516
Echinococcus granulosus muscleblind protein 0.0149 1 1
Toxoplasma gondii TIM10 family protein, putative 0.0048 0.3012 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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