Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Leishmania major | thymidine kinase, putative | 0.0057307 | 0.467403 | 0.467403 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0057307 | 0.467403 | 0.467403 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.00844282 | 1 | 0.5 |
Leishmania major | thymidine kinase, putative | 0.0057307 | 0.467403 | 0.467403 |
Trypanosoma brucei | thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Giardia lamblia | CDC8 | 0.00844282 | 1 | 1 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.00844282 | 1 | 0.5 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.00844282 | 1 | 0.5 |
Giardia lamblia | CDC8 | 0.00844282 | 1 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0057307 | 0.467403 | 0.467403 |
Toxoplasma gondii | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Plasmodium vivax | thymidylate kinase, putative | 0.00844282 | 1 | 0.5 |
Schistosoma mansoni | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Echinococcus granulosus | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Chlamydia trachomatis | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Echinococcus granulosus | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.00844282 | 1 | 0.5 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Chlamydia trachomatis | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Trypanosoma brucei | thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Plasmodium falciparum | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.00844282 | 1 | 0.5 |
Brugia malayi | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Trypanosoma brucei | thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Onchocerca volvulus | Putative thymidylate kinase | 0.00844282 | 1 | 0.5 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Mycobacterium ulcerans | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Onchocerca volvulus | Putative thymidylate kinase | 0.00844282 | 1 | 0.5 |
Plasmodium vivax | thymidylate kinase, putative | 0.00844282 | 1 | 0.5 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.00844282 | 1 | 0.5 |
Schistosoma mansoni | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Leishmania major | thymidylate kinase-like protein | 0.00844282 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0057307 | 0.467403 | 0.467403 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.00844282 | 1 | 0.5 |
Schistosoma mansoni | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0057307 | 0.467403 | 0.467403 |
Echinococcus multilocularis | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Brugia malayi | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Leishmania major | thymidylate kinase-like protein | 0.00844282 | 1 | 1 |
Mycobacterium ulcerans | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.00844282 | 1 | 0.5 |
Schistosoma mansoni | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Plasmodium falciparum | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.00844282 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.00844282 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = -7.26 | Antiamoebic activity against Entamoeba histolytica | ChEMBL. | 17074492 |
IC50 (functional) | = 0.055 uM | The compound was tested in vitro against the protozoa Entamoeba histolytica, for the inhibition of tubulin polymerization in rat brain | ChEMBL. | 12127542 |
IC50 (functional) | = 0.055 uM | The compound was tested in vitro against the protozoa Entamoeba histolytica, for the inhibition of tubulin polymerization in rat brain | ChEMBL. | 12127542 |
IC50 (functional) | = 0.078 uM | The compound was tested in vitro against the protozoa Giardia lamblia, for the inhibition of tubulin polymerization in rat brain | ChEMBL. | 12127542 |
Log IC50 (functional) | = 7.26 | Antiamoebic activity against Entamoeba histolytica | ChEMBL. | 17074492 |
Viability (functional) | = 23 % | Percentage viability reduction of Trichinella spiralis muscle larvae after 3 days of incubation | ChEMBL. | 12127542 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Entamoeba histolytica | ChEMBL23 | 12127542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.