Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0094 | 0 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0094 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2913 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0094 | 0 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0094 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0094 | 0 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0094 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0094 | 0 | 0.5 |
Onchocerca volvulus | 0.0094 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0094 | 0 | 0.5 |
Onchocerca volvulus | 0.0094 | 0 | 0.5 | |
Echinococcus granulosus | peroxidasin | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2913 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.2913 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50 uM | Immunosuppressive activity of the compound expressed as ability to inhibit human recombinant dihydroorotate dehydrogenase (DHODH) | ChEMBL. | 9873513 |
IC50 (binding) | > 50 uM | Immunosuppressive activity of the compound expressed as ability to inhibit human recombinant dihydroorotate dehydrogenase (DHODH) | ChEMBL. | 9873513 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.