Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phospholipase D2 | Starlite/ChEMBL | References |
Homo sapiens | phospholipase D1, phosphatidylcholine-specific | Starlite/ChEMBL | References |
Rattus norvegicus | Phospholipase D1 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | phospholipase D active site domain-containing protein | 0.0151 | 0.7586 | 0.7922 |
Echinococcus granulosus | tar DNA binding protein | 0.0141 | 0.6947 | 0.6947 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1081 | 0.1081 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.0063 | 0.1482 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0186 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.6947 | 0.7255 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0186 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.7586 | 0.7586 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0186 | 1 | 1 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0063 | 0.1482 | 0.1482 |
Echinococcus granulosus | phospholipase D1 | 0.0179 | 0.9576 | 0.9576 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0041 | 0 | 0.5 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0063 | 0.1482 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0186 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.7586 | 0.7586 |
Brugia malayi | TAR-binding protein | 0.0141 | 0.6947 | 0.6947 |
Loa Loa (eye worm) | RNA binding protein | 0.0141 | 0.6947 | 0.6947 |
Echinococcus multilocularis | phospholipase D | 0.0158 | 0.8125 | 0.8125 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.016 | 0.821 | 0.8574 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.1081 | 0.1081 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0041 | 0 | 0.5 |
Trypanosoma brucei | cardiolipin synthetase | 0.0063 | 0.1482 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.0179 | 0.9576 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0141 | 0.6947 | 0.6947 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.6947 | 0.7255 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | phospholipase D | 0.0179 | 0.9576 | 1 |
Echinococcus granulosus | phospholipase D | 0.0158 | 0.8125 | 0.8125 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.5242 | 0.5242 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0041 | 0 | 0.5 |
Onchocerca volvulus | 0.0107 | 0.4581 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.6947 | 0.7255 |
Brugia malayi | Phospholipase d protein 1 | 0.0179 | 0.9576 | 0.9576 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0063 | 0.1482 | 1 |
Trypanosoma brucei | cardiolipin synthetase, putative | 0.0063 | 0.1482 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0141 | 0.6947 | 0.6947 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0041 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0141 | 0.6947 | 0.6947 |
Schistosoma mansoni | alpha-glucosidase | 0.016 | 0.821 | 0.8574 |
Echinococcus multilocularis | tar DNA binding protein | 0.0141 | 0.6947 | 0.6947 |
Echinococcus multilocularis | phospholipase D1 | 0.0179 | 0.9576 | 0.9576 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0041 | 0 | 0.5 |
Entamoeba histolytica | phospholipase D, putative | 0.0179 | 0.9576 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.6947 | 0.7255 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0041 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0141 | 0.6947 | 0.6947 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.1081 | 0.1081 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.5242 | 0.5242 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.6947 | 0.7255 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.1081 | 0.1081 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.3 nM | Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis | ChEMBL. | 19136975 |
IC50 (binding) | = 55 nM | Inhibition of human PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay | ChEMBL. | 19136975 |
IC50 (binding) | = 130 nM | Inhibition of human PLD2 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay | ChEMBL. | 19136975 |
IC50 (binding) | = 140 nM | Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis | ChEMBL. | 19136975 |
IC50 (binding) | = 910 nM | Inhibition of N-terminally truncated rat PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay | ChEMBL. | 19136975 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.