Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3033 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3033 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3033 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3033 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0037 | 0.3033 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.