Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.0091 | 0.4255 | 0.1439 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0091 | 0.4255 | 0.4255 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0139 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0083 | 0.3289 | 0.3289 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0107 | 0.6138 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.158 uM | Compound potency to achieve protection of MT-4 cells from HIV-1 cytopathicity | ChEMBL. | 11527703 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.