Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.5495 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0751 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.6134 | 0.582 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.5495 | 0.8577 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0751 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0751 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.1647 | 0.0969 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0751 | 1 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.5495 | 0.513 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0751 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0751 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.1647 | 0.0969 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0751 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0751 | 0.0751 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.5495 | 0.8577 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.5495 | 0.8577 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0751 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.6134 | 0.6134 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0751 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0751 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1647 | 0.1647 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 1 | 1 |
Onchocerca volvulus | 0.0024 | 0.0751 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0751 | 0.0751 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.5495 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.5495 | 0.513 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.5495 | 0.5495 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0751 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0751 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.5495 | 0.8577 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0751 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0751 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0751 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.5495 | 0.5495 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0751 | 0.0751 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0751 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.5495 | 0.8577 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.5495 | 0.5495 |
Brugia malayi | RNA binding protein | 0.0063 | 0.5495 | 0.513 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0751 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0751 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.1647 | 0.1647 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.6134 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.