Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 32.1 uM | Cytotoxicity against human MT4 cells after 4 days by MTT assay | ChEMBL. | 20638854 |
IC50 (ADMET) | = 8.4 uM | Cytotoxicity against human THP1 cells using propidium iodide staining after 72 hrs by flow cytometry | ChEMBL. | 20638854 |
IC50 (functional) | = 11.3 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as inhibition of parasite proliferation after 48 hrs | ChEMBL. | 20638854 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20638854 | |
Homo sapiens | ChEMBL23 | 20638854 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.