Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0071 | 0.5908 | 0.4609 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0056 | 0.4297 | 0.5056 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.2514 | 0.5 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0086 | 0.7652 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.2158 | 0.2062 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0107 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0867 | 0.0991 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0107 | 1 | 1 |
Brugia malayi | Inositol-1 | 0.0041 | 0.2514 | 0.2427 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0103 | 0.9597 | 0.9469 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.2514 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0867 | 0.0991 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0056 | 0.4297 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.7652 | 1 |
Onchocerca volvulus | 0.0026 | 0.0867 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0867 | 0.0755 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.2032 | 0.1717 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.7652 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.2514 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.2514 | 0.2422 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.003 | 0.1269 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0867 | 0.0755 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.003 | 0.1269 | 0.1526 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.2514 | 0.0454 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.2032 | 0.4728 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2409 | 0.2317 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.7652 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0867 | 0.0991 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0867 | 0.0991 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5505 | 0.5451 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.2514 | 0.0137 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.012 | 0.028 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.4122 | 0.405 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.4122 | 0.4797 |
Brugia malayi | Transient-receptor-potential like protein | 0.004 | 0.2409 | 0.2274 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.2514 | 0.1949 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.4122 | 0.4797 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.7652 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0086 | 0.7652 | 0.6906 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0103 | 0.9597 | 0.9469 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0867 | 0.0991 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.7652 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0867 | 0.0755 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.2514 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0867 | 0.0991 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.2514 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0071 | 0.5908 | 0.4782 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0071 | 0.5908 | 0.4609 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0867 | 0.2017 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.2158 | 0.1903 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.4122 | 0.405 |
Schistosoma mansoni | transient receptor potential channel | 0.0107 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.2514 | 0.0454 |
Schistosoma mansoni | transient receptor potential channel | 0.0071 | 0.5908 | 0.4782 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0056 | 0.4297 | 0.2487 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.7652 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0086 | 0.7652 | 0.7006 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0086 | 0.7652 | 0.6906 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.003 | 0.1269 | 0.1526 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0056 | 0.4297 | 0.2487 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.2514 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.7652 | 0.7623 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.2007 | 0.1909 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0071 | 0.5908 | 0.4609 |
Brugia malayi | Probable ClpP-like protease | 0.0086 | 0.7652 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0867 | 0.0991 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0867 | 0.2017 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0086 | 0.7652 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0071 | 0.5908 | 0.4609 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0056 | 0.4297 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.2514 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0086 | 0.7652 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0086 | 0.7652 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.7652 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0867 | 0.0991 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0041 | 0.2514 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0.2514 | 0.3178 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.2514 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.