Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 3A, cGMP-inhibited | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132613 | All targets in OG5_132613 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | Get druggable targets OG5_132613 | All targets in OG5_132613 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132613 | All targets in OG5_132613 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0191 | 0.131 | 0.131 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0191 | 0.131 | 0.131 |
Brugia malayi | hypothetical protein | 0.0191 | 0.131 | 0.131 |
Onchocerca volvulus | 0.0332 | 0.5125 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0191 | 0.131 | 0.131 |
Onchocerca volvulus | 0.0176 | 0.0923 | 0.18 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0332 | 0.5125 | 0.5125 |
Loa Loa (eye worm) | hypothetical protein | 0.05 | 0.9635 | 0.9635 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0191 | 0.131 | 0.131 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0191 | 0.131 | 0.131 |
Onchocerca volvulus | 0.0332 | 0.5125 | 1 | |
Onchocerca volvulus | 0.0332 | 0.5125 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.131 | 0.131 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.131 | 0.131 |
Onchocerca volvulus | 0.0332 | 0.5125 | 1 | |
Onchocerca volvulus | 0.0191 | 0.131 | 0.2556 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0332 | 0.5125 | 0.5125 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.0923 | 0.0923 |
Onchocerca volvulus | 0.0191 | 0.131 | 0.2556 | |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.131 | 0.131 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0332 | 0.5125 | 0.5125 |
Onchocerca volvulus | 0.0332 | 0.5125 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.131 | 0.131 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0332 | 0.5125 | 0.5125 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.131 | 0.131 |
Brugia malayi | hypothetical protein | 0.0176 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5125 | 0.5125 |
Onchocerca volvulus | 0.0332 | 0.5125 | 1 | |
Onchocerca volvulus | 0.0332 | 0.5125 | 1 | |
Onchocerca volvulus | 0.0332 | 0.5125 | 1 | |
Brugia malayi | hypothetical protein | 0.0191 | 0.131 | 0.131 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.0084 nM | Inhibition of human platelet aggregation induced by ADP after 15 min incubation with platelet rich plasma | ChEMBL. | 8230115 |
IC50 (functional) | = 0.03 nM | Inhibition of human platelet aggregation induced by ADP after 3 min incubation with platelet rich plasma | ChEMBL. | 8230115 |
IC50 (functional) | = 1.13 nM | Inhibition of human platelet aggregation cAMP PDE in vitro | ChEMBL. | 8230115 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 8230115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.