Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.6068 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.6068 | 0.5 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0035 | 0.6068 | 0.6068 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 0.6068 | 0.5 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 0.6068 | 0.5 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 0.6068 | 0.5 |
Brugia malayi | Augmenter of liver regeneration | 0.0035 | 0.6068 | 0.6068 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.6068 | 0.6068 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.6068 | 0.5 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.6068 | 0.6068 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.6068 | 0.5 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 0.6068 | 0.5 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.6068 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 82 % | Inhibition of LPS-induced NO production in mouse BV2 microglia cells assessed as nitrite levels at 100 uM relative to untreated control | ChEMBL. | 17980460 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.