Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.4591 | 0.4591 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1771 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1767 | 0.3848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.4591 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1771 | 0.1771 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1771 | 0.3857 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.4591 | 0.4591 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.4591 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.4591 | 0.4591 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.4591 | 1 |
Brugia malayi | RNA binding protein | 0.0065 | 0.4591 | 0.4591 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1771 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.4591 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.3289 | 0.3289 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.4591 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1767 | 0.1767 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1771 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1771 | 0.3857 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.4591 | 1 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.3289 | 0.3289 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1767 | 0.1767 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1771 | 0.3857 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1771 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.4591 | 0.4591 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1771 | 0.3857 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.4591 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 15 uM | Cytotoxicity against HFF cells after 3 days by natural red dye uptake assay | ChEMBL. | 20167488 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.