Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0359 | 0.6284 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0558 | 1 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0073 | 0.0938 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0359 | 0.6284 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0359 | 0.6284 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.6284 | 0.4692 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0073 | 0.0938 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0073 | 0.0938 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC90 (functional) | = 4.7 uM | Antimycobacterial activity against non replicating persistent form of Mycobacterium tuberculosis H37Rv after 10 days by low oxygen recovery assay | ChEMBL. | 19757815 |
MIC90 (functional) | = 6.3 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv replicating form by alamar blue assay | ChEMBL. | 19757815 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.