Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | kinesin, putative | 0.0032 | 0.0579 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1186 | 0.138 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0032 | 0.0579 | 0.4879 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1186 | 0.1186 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1186 | 0.1186 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1186 | 0.1186 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0032 | 0.0579 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0032 | 0.0579 | 0.4879 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1186 | 0.1186 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1186 | 0.138 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1186 | 1 |
Echinococcus granulosus | geminin | 0.0174 | 0.679 | 0.679 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.679 | 0.7901 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.8593 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1186 | 0.138 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0032 | 0.0579 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | kinesin eg-5 | 0.0032 | 0.0579 | 0.0673 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0174 | 0.679 | 0.679 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0032 | 0.0579 | 1 |
Plasmodium vivax | kinesin-5 | 0.0032 | 0.0579 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1186 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.679 | 0.7901 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.32 uM | Inhibition of human full-length Eg5 ATPase activity expressed in Escherichia coli assessed as release of inorganic phosphate after 30 mins | ChEMBL. | 20934346 |
IC50 (functional) | = 10.12 uM | Cytotoxicity against human A2780 cells after 72 hrs by MTT assay | ChEMBL. | 20934346 |
IC50 (functional) | = 11.56 uM | Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay | ChEMBL. | 20934346 |
IC50 (binding) | > 50 uM | Inhibition of human purified recombinant aurora-A kinase | ChEMBL. | 20934346 |
IC50 (functional) | > 50 uM | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay | ChEMBL. | 20934346 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 20934346 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.