Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.5929 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.5929 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0037 | 0.5929 | 0.5929 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.5371 | 0.906 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.5929 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.5929 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.5929 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.5371 | 0.5371 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.5929 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.5929 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.5929 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.5371 | 0.5371 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 73.9 uM | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | ChEMBL. | 20673727 |
IC50 (functional) | > 200 uM | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay | ChEMBL. | 20673727 |
IC50 (functional) | > 200 uM | Cytotoxicity against human CNE cells after 72 hrs by MTT assay | ChEMBL. | 20673727 |
IC50 (functional) | > 200 uM | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay | ChEMBL. | 20673727 |
IC50 (functional) | > 200 uM | Cytotoxicity against human K562 cells after 72 hrs by MTT assay | ChEMBL. | 20673727 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.