Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0037 | 0 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0889 | 1 | 1 |
Leishmania major | pteridine reductase 1 | 0.0658 | 0.7288 | 0.7288 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0889 | 1 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0649 | 0.7187 | 0.7187 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0037 | 0 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0889 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0889 | 1 | 1 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.