Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | aminopeptidase, putative | 0.0158 | 0.6765 | 0.5 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0158 | 0.6765 | 1 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0158 | 0.6765 | 1 |
Trypanosoma brucei | aspartyl aminopeptidase, putative | 0.0158 | 0.6765 | 0.5 |
Brugia malayi | Aspartyl aminopeptidase | 0.0158 | 0.6765 | 1 |
Plasmodium vivax | M18 aspartyl aminopeptidase, putative | 0.0158 | 0.6765 | 0.5 |
Leishmania major | aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 | 0.0158 | 0.6765 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.6765 | 1 |
Trypanosoma brucei | aspartyl aminopeptidase, putative | 0.0158 | 0.6765 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MH, Family M20 | 0.0158 | 0.6765 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Entamoeba histolytica | aspartyl aminopeptidase, putative | 0.0158 | 0.6765 | 0.5 |
Plasmodium falciparum | M18 aspartyl aminopeptidase | 0.0158 | 0.6765 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.6765 | 1 |
Mycobacterium leprae | PROBABLE AMINOPEPTIDASE PEPC | 0.0158 | 0.6765 | 0.5 |
Loa Loa (eye worm) | aspartyl aminopeptidase | 0.0158 | 0.6765 | 1 |
Trypanosoma cruzi | aspartyl aminopeptidase, putative | 0.0158 | 0.6765 | 0.5 |
Mycobacterium tuberculosis | Probable aminopeptidase PepC | 0.0158 | 0.6765 | 0.5 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0158 | 0.6765 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.6626 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.