Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0186 | 0.4197 | 0.4091 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0072 | 0.1049 | 0.25 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0144 | 0.3038 | 0.2367 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0144 | 0.3038 | 0.7239 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0433 | 0.0259 |
Echinococcus granulosus | prolyl endopeptidase | 0.0144 | 0.3038 | 0.7239 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0072 | 0.1049 | 0.25 |
Trypanosoma brucei | prolyl endopeptidase | 0.0144 | 0.3038 | 0.2367 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0045 | 0.0329 | 0.0784 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0186 | 0.4197 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0397 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0072 | 0.1049 | 0.0186 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0072 | 0.1049 | 0.0186 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0065 | 0.088 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0072 | 0.1049 | 0.0186 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0072 | 0.1049 | 0.25 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0144 | 0.3038 | 0.2367 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.3038 | 0.2912 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0144 | 0.3038 | 0.7239 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0297 | 0.0121 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0186 | 0.4197 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0072 | 0.1049 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0397 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.004 | 0.0178 | 0.0104 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0144 | 0.3038 | 0.2985 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0065 | 0.088 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0397 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0144 | 0.3038 | 0.7239 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0117 | 0.2286 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0049 | 0.0433 | 0.1031 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0072 | 0.1049 | 0.0186 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0072 | 0.1049 | 0.0981 |
Brugia malayi | hypothetical protein | 0.0044 | 0.0297 | 0.0224 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0049 | 0.0433 | 0.1031 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0186 | 0.4197 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4661 | 0.4564 |
Toxoplasma gondii | prolyl endopeptidase | 0.0144 | 0.3038 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0186 | 0.4197 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0186 | 0.4197 | 0.4153 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.